Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d)
1_MSMSP 6_ TVIIL 11_ ACLGF 16_ FLDQS 21_ VWAHV 26_ GGQDK 31_ PFCSA 36_ WPSAV 41_ VPQGG 46_ HVTLR 51_ CHYRR 56_ GFNIF 61_ TLYKK 66_ DGVPV 71_ PELYN 76_ RIFWN 81_ SFLIS 86_ PVTPA 91_ HAGTY 96_ RCRGF 101_ HPHSP 106_ TEWSA 111_ PSNPL 116_ VIMVT 121_ GLYEK 126_ PSLTA 131_ RPGPT 136_ VRAGE 141_ NVTLS 146_ CSSQS 151_ SFDIY 156_ HLSRE 161_ GEAHE 166_ LRLPA 171_ VPSIN 176_ GTFQA 181_ DFPLG 186_ PATHG 191_ ETYRC 196_ FGSFH 201_ GSPYE 206_ WSDPS 211_ DPLPV 216_ SVTGN 221_ PSSSW 226_ PSPTE 231_ PSFKT 236_ GIARH 241_ LHAVI 246_ RYSVA 251_ IILFT 256_ ILPFF 261_ LLHRW 266_ CSKKK 271_ DAAVM 276_ NQEPA 281_ GHRTV 286_ NREDS 291_ DEQDP 296_ QEVTY 301_ AQLDH 306_ CIFTQ 311_ RKITG 316_ PSQRS 321_ KRPST 326_ DTSVC 331_ IELPN 336_ AEPRA 341_ LSPAH 346_ EHHSQ 351_ ALMGS 356_ SRETT 361_ ALSQT 366_ QLASS 371_NVPAA
1: Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272)