Methionine synthase (MS) (EC 2.1.1.13) (5-methyltetrahydrofolate--homocysteine methyltransferase) (Cobalamin-dependent methionine synthase) (Vitamin-B12 dependent methionine synthase)
1_MSPAL 6_ QDLSQ 11_ PEGLK 16_ KTLRD 21_ EINAI 26_ LQKRI 31_ MVLDG 36_ GMGTM 41_ IQREK 46_ LNEEH 51_ FRGQE 56_ FKDHA 61_ RPLKG 66_ NNDIL 71_ SITQP 76_ DVIYQ 81_ IHKEY 86_ LLAGA 91_ DIIET 96_ NTFSS 101_ TSIAQ 106_ ADYGL 111_ EHLAY 116_ RMNMC 121_ SAGVA 126_ RKAAE 131_ EVTLQ 136_ TGIKR 141_ FVAGA 146_ LGPTN 151_ KTLSV 156_ SPSVE 161_ RPDYR 166_ NITFD 171_ ELVEA 176_ YQEQA 181_ KGLLD 186_ GGVDI 191_ LLIET 196_ IFDTA 201_ NAKAA 206_ LFALQ 211_ NLFEE 216_ KYAPR 221_ PIFIS 226_ GTIVD 231_ KSGRT 236_ LSGQT 241_ GEGFV 246_ ISVSH 251_ GEPLC 256_ IGLNC 261_ ALGAA 266_ EMRPF 271_ IEIIG 276_ KCTTA 281_ YVLCY 286_ PNAGL 291_ PNTFG 296_ DYDET 301_ PSMMA 306_ KHLKD 311_ FAMDG 316_ LVNIV 321_ GGCCG 326_ STPDH 331_ IREIA 336_ EAVKN 341_ CKPRV 346_ PPATA 351_ FEGHM 356_ LLSGL 361_ EPFRI 366_ GPYTN 371_ FVNIG 376_ ERCNV 381_ AGSRK 386_ FAKLI 391_ MAGNY 396_ EEALC 401_ VAKVQ 406_ VEMGA 411_ QVLDV 416_ NMDDG 421_ MLDGP 426_ SAMTR 431_ FCNLI 436_ ASEPD 441_ IAKVP 446_ LCIDS 451_ SNFAV 456_ IEAGL 461_ KCCQG 466_ KCIVN 471_ SISLK 476_ EGEDD 481_ FLEKA 486_ RKIKK 491_ YGAAM 496_ VVMAF 501_ DEEGQ 506_ ATETD 511_ TKIRV 516_ CTRAY 521_ HLLVK 526_ KLGFN 531_ PNDII 536_ FDPNI 541_ LTIGT 546_ GMEEH 551_ NLYAI 556_ NFIHA 561_ TKVIK 566_ ETLPG 571_ ARISG 576_ GLSNL 581_ SFSFR 586_ GMEAI 591_ REAMH 596_ GVFLY 601_ HAIKS 606_ GMDMG 611_ IVNAG 616_ NLPVY 621_ DDIHK 626_ ELLQL 631_ CEDLI 636_ WNKDP 641_ EATEK 646_ LLRYA 651_ QTQGT 656_ GGKKV 661_ IQTDE 666_ WRNGP 671_ VEERL 676_ EYALV 681_ KGIEK 686_ HIIED 691_ TEEAR 696_ LNQKK 701_ YPRPL 706_ NIIEG 711_ PLMNG 716_ MKIVG 721_ DLFGA 726_ GKMFL 731_ PQVIK 736_ SARVM 741_ KKAVG 746_ HLIPF 751_ MEKER 756_ EETRV 761_ LNGTV 766_ EEEDP 771_ YQGTI 776_ VLATV 781_ KGDVH 786_ DIGKN 791_ IVGVV 796_ LGCNN 801_ FRVID 806_ LGVMT 811_ PCDKI 816_ LKAAL 821_ DHKAD 826_ IIGLS 831_ GLITP 836_ SLDEM 841_ IFVAK 846_ EMERL 851_ AIRIP 856_ LLIGG 861_ ATTSK 866_ THTAV 871_ KIAPR 876_ YSAPV 881_ IHVLD 886_ ASKSV 891_ VVCSQ 896_ LLDEN 901_ LKDEY 906_ FEEIM 911_ EEYED 916_ IRQDH 921_ YESLK 926_ ERRYL 931_ PLSQA 936_ RKSGF 941_ QMDWL 946_ SEPHP 951_ VKPTF 956_ IGTQV 961_ FEDYD 966_ LQKLV 971_ DYIDW 976_ KPFFD 981_ VWQLR 986_ GKYPN 991_ RGFPK 996_ IFNDK 1001_ TVGGE 1006_ ARKVY 1011_ DDAHN 1016_ MLNTL 1021_ ISQKK 1026_ LRARG 1031_ VVGFW 1036_ PAQSI 1041_ QDDIH 1046_ LYAEA 1051_ AVPQA 1056_ AEPIA 1061_ TFYGL 1066_ RQQAE 1071_ KDSAS 1076_ TEPYY 1081_ CLSDF 1086_ IAPLH 1091_ SGIRD 1096_ YLGLF 1101_ AVACF 1106_ GVEEL 1111_ SKAYE 1116_ DDGDD 1121_ YSSIM 1126_ VKALG 1131_ DRLAE 1136_ AFAEE 1141_ LHERV 1146_ RRELW 1151_ AYCGS 1156_ EQLDV 1161_ ADLRR 1166_ LRYKG 1171_ IRPAP 1176_ GYPSQ 1181_ PDHTE 1186_ KLTMW 1191_ RLADI 1196_ EQSTG 1201_ IRLTE 1206_ SLAMA 1211_ PASAV 1216_ SGLYF 1221_ SNLKS 1226_ KYFAV 1231_ GKISK 1236_ DQVED 1241_ YALRK 1246_ NISVA 1251_ EVEKW 1256_LGPIL
1: Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:17288554, PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510)