Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (JV5-1) (SMAD family member 5) (SMAD 5) (Smad5) (hSmad5)
1_MTSMA 6_ SLFSF 11_ TSPAV 16_ KRLLG 21_ WKQGD 26_ EEEKW 31_ AEKAV 36_ DALVK 41_ KLKKK 46_ KGAME 51_ ELEKA 56_ LSSPG 61_ QPSKC 66_ VTIPR 71_ SLDGR 76_ LQVSH 81_ RKGLP 86_ HVIYC 91_ RVWRW 96_ PDLQS 101_ HHELK 106_ PLDIC 111_ EFPFG 116_ SKQKE 121_ VCINP 126_ YHYKR 131_ VESPV 136_ LPPVL 141_ VPRHN 146_ EFNPQ 151_ HSLLV 156_ QFRNL 161_ SHNEP 166_ HMPQN 171_ ATFPD 176_ SFHQP 181_ NNTPF 186_ PLSPN 191_ SPYPP 196_ SPASS 201_ TYPNS 206_ PASSG 211_ PGSPF 216_ QLPAD 221_ TPPPA 226_ YMPPD 231_ DQMGQ 236_ DNSQP 241_ MDTSN 246_ NMIPQ 251_ IMPSI 256_ SSRDV 261_ QPVAY 266_ EEPKH 271_ WCSIV 276_ YYELN 281_ NRVGE 286_ AFHAS 291_ STSVL 296_ VDGFT 301_ DPSNN 306_ KSRFC 311_ LGLLS 316_ NVNRN 321_ STIEN 326_ TRRHI 331_ GKGVH 336_ LYYVG 341_ GEVYA 346_ ECLSD 351_ SSIFV 356_ QSRNC 361_ NFHHG 366_ FHPTT 371_ VCKIP 376_ SSCSL 381_ KIFNN 386_ QEFAQ 391_ LLAQS 396_ VNHGF 401_ EAVYE 406_ LTKMC 411_ TIRMS 416_ FVKGW 421_ GAEYH 426_ RQDVT 431_ STPCW 436_ IEIHL 441_ HGPLQ 446_ WLDKV 451_ LTQMG 456_SPLNP
1: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158)