Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)
1_MQWAV 6_ GRRWA 11_ WAALL 16_ LAVAA 21_ VLTQV 26_ VWLWL 31_ GTQSF 36_ VFQRE 41_ EIAQL 46_ ARQYA 51_ GLDHE 56_ LAFSR 61_ LIVEL 66_ RRLHP 71_ GHVLP 76_ DEELQ 81_ WVFVN 86_ AGGWM 91_ GAMCL 96_ LHASL 101_ SEYVL 106_ LFGTA 111_ LGSRG 116_ HSGRY 121_ WAEIS 126_ DTIIS 131_ GTFHQ 136_ WREGT 141_ TKSEV 146_ FYPGE 151_ TVVHG 156_ PGEAT 161_ AVEWG 166_ PNTWM 171_ VEYGR 176_ GVIPS 181_ TLAFA 186_ LADTV 191_ FSTQD 196_ FLTLF 201_ YTLRS 206_ YARGL 211_ RLELT 216_TYLFG
1: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (PubMed:16472803, PubMed:9341151). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity)