Metalloproteinase inhibitor 4 (Tissue inhibitor of metalloproteinases 4) (TIMP-4)
1_MPGSP 6_ RPAPS 11_ WVLLL 16_ RLLAL 21_ LRPPG 26_ LGEAC 31_ SCAPA 36_ HPQQH 41_ ICHSA 46_ LVIRA 51_ KISSE 56_ KVVPA 61_ SADPA 66_ DTEKM 71_ LRYEI 76_ KQIKM 81_ FKGFE 86_ KVKDV 91_ QYIYT 96_ PFDSS 101_ LCGVK 106_ LEANS 111_ QKQYL 116_ LTGQV 121_ LSDGK 126_ VFIHL 131_ CNYIE 136_ PWEDL 141_ SLVQR 146_ ESLNH 151_ HYHLN 156_ CGCQI 161_ TTCYT 166_ VPCTI 171_ SAPNE 176_ CLWTD 181_ WLLER 186_ KLYGY 191_ QAQHY 196_ VCMKH 201_ VDGTC 206_ SWYRG 211_ HLPLR 216_KEFVD
1: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9