BRCA1-associated RING domain protein 1 (BARD-1) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BARD1)
1_MPDNR 6_ QPRNR 11_ QPRIR 16_ SGNEP 21_ RSAPA 26_ MEPDG 31_ RGAWA 36_ HSRAA 41_ LDRLE 46_ KLLRC 51_ SRCTN 56_ ILREP 61_ VCLGG 66_ CEHIF 71_ CSNCV 76_ SDCIG 81_ TGCPV 86_ CYTPA 91_ WIQDL 96_ KINRQ 101_ LDSMI 106_ QLCSK 111_ LRNLL 116_ HDNEL 121_ SDLKE 126_ DKPRK 131_ SLFND 136_ AGNKK 141_ NSIKM 146_ WFSPR 151_ SKKVR 156_ YVVSK 161_ ASVQT 166_ QPAIK 171_ KDASA 176_ QQDSY 181_ EFVSP 186_ SPPAD 191_ VSERA 196_ KKASA 201_ RSGKK 206_ QKKKT 211_ LAEIN 216_ QKWNL 221_ EAEKE 226_ DGEFD 231_ SKEES 236_ KQKLV 241_ SFCSQ 246_ PSVIS 251_ SPQIN 256_ GEIDL 261_ LASGS 266_ LTESE 271_ CFGSL 276_ TEVSL 281_ PLAEQ 286_ IESPD 291_ TKSRN 296_ EVVTP 301_ EKVCK 306_ NYLTS 311_ KKSLP 316_ LENNG 321_ KRGHH 326_ NRLSS 331_ PISKR 336_ CRTSI 341_ LSTSG 346_ DFVKQ 351_ TVPSE 356_ NIPLP 361_ ECSSP 366_ PSCKR 371_ KVGGT 376_ SGRKN 381_ SNMSD 386_ EFISL 391_ SPGTP 396_ PSTLS 401_ SSSYR 406_ RVMSS 411_ PSAMK 416_ LLPNM 421_ AVKRN 426_ HRGET 431_ LLHIA 436_ SIKGD 441_ IPSVE 446_ YLLQN 451_ GSDPN 456_ VKDHA 461_ GWTPL 466_ HEACN 471_ HGHLK 476_ VVELL 481_ LQHKA 486_ LVNTT 491_ GYQND 496_ SPLHD 501_ AAKNG 506_ HVDIV 511_ KLLLS 516_ YGASR 521_ NAVNI 526_ FGLRP 531_ VDYTD 536_ DESMK 541_ SLLLL 546_ PEKNE 551_ SSSAS 556_ HCSVM 561_ NTGQR 566_ RDGPL 571_ VLIGS 576_ GLSSE 581_ QQKML 586_ SELAV 591_ ILKAK 596_ KYTEF 601_ DSTVT 606_ HVVVP 611_ GDAVQ 616_ STLKC 621_ MLGIL 626_ NGCWI 631_ LKFEW 636_ VKACL 641_ RRKVC 646_ EQEEK 651_ YEIPE 656_ GPRRS 661_ RLNRE 666_ QLLPK 671_ LFDGC 676_ YFYLW 681_ GTFKH 686_ HPKDN 691_ LIKLV 696_ TAGGG 701_ QILSR 706_ KPKPD 711_ SDVTQ 716_ TINTV 721_ AYHAR 726_ PDSDQ 731_ RFCTQ 736_ YIIYE 741_ DLCNY 746_ HPERV 751_ RQGKV 756_ WKAPS 761_ SWFID 766_ CVMSF 771_ELLPL
1: E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage