Neurturin
1_MQRWK 6_ AAALA 11_ SVLCS 16_ SVLSI 21_ WMCRE 26_ GLLLS 31_ HRLGP 36_ ALVPL 41_ HRLPR 46_ TLDAR 51_ IARLA 56_ QYRAL 61_ LQGAP 66_ DAMEL 71_ RELTP 76_ WAGRP 81_ PGPRR 86_ RAGPR 91_ RRRAR 96_ ARLGA 101_ RPCGL 106_ RELEV 111_ RVSEL 116_ GLGYA 121_ SDETV 126_ LFRYC 131_ AGACE 136_ AAARV 141_ YDLGL 146_ RRLRQ 151_ RRRLR 156_ RERVR 161_ AQPCC 166_ RPTAY 171_ EDEVS 176_ FLDAH 181_ SRYHT 186_ VHELS 191_ARECA
1: Growth factor that supports the survival of sympathetic neurons in culture (PubMed:8945474). May regulate the development and maintenance of the CNS (PubMed:8945474). Involved in the development of the neural crest (PubMed:15242795). Might control the size of non-neuronal cell population such as haemopoietic cells (PubMed:8945474). Acts by binding to its coreceptor, GFRA2, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:29414779, PubMed:31535977). Heparan sulfate-binding is required for signaling (PubMed:29414779)