Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]
1_MAVLR 6_ QLALL 11_ LWKNY 16_ TLQKR 21_ KVLVT 26_ VLELF 31_ LPLLF 36_ SGILI 41_ WLRLK 46_ IQSEN 51_ VPNAT 56_ IYPGQ 61_ SIQEL 66_ PLFFT 71_ FPPPG 76_ DTWEL 81_ AYIPS 86_ HSDAA 91_ KTVTE 96_ TVRRA 101_ LVINM 106_ RVRGF 111_ PSEKD 116_ FEDYI 121_ RYDNC 126_ SSSVL 131_ AAVVF 136_ EHPFN 141_ HSKEP 146_ LPLAV 151_ KYHLR 156_ FSYTR 161_ RNYMW 166_ TQTGS 171_ FFLKE 176_ TEGWH 181_ TTSLF 186_ PLFPN 191_ PGPRE 196_ PTSPD 201_ GGEPG 206_ YIREG 211_ FLAVQ 216_ HAVDR 221_ AIMEY 226_ HADAA 231_ TRQLF 236_ QRLTV 241_ TIKRF 246_ PYPPF 251_ IADPF 256_ LVAIQ 261_ YQLPL 266_ LLLLS 271_ FTYTA 276_ LTIAR 281_ AVVQE 286_ KERRL 291_ KEYMR 296_ MMGLS 301_ SWLHW 306_ SAWFL 311_ LFFLF 316_ LLIAA 321_ SFMTL 326_ LFCVK 331_ VKPNV 336_ AVLSR 341_ SDPSL 346_ VLAFL 351_ LCFAI 356_ STISF 361_ SFMVS 366_ TFFSK 371_ ANMAA 376_ AFGGF 381_ LYFFT 386_ YIPYF 391_ FVAPR 396_ YNWMT 401_ LSQKL 406_ CSCLL 411_ SNVAM 416_ AMGAQ 421_ LIGKF 426_ EAKGM 431_ GIQWR 436_ DLLSP 441_ VNVDD 446_ DFCFG 451_ QVLGM 456_ LLLDS 461_ VLYGL 466_ VTWYM 471_ EAVFP 476_ GQFGV 481_ PQPWY 486_ FFIMP 491_ SYWCG 496_ KPRAV 501_ AGKEE 506_ EDSDP 511_ EKALR 516_ NEYFE 521_ AEPED 526_ LVAGI 531_ KIKHL 536_ SKVFR 541_ VGNKD 546_ RAAVR 551_ DLNLN 556_ LYEGQ 561_ ITVLL 566_ GHNGA 571_ GKTTT 576_ LSMLT 581_ GLFPP 586_ TSGRA 591_ YISGY 596_ EISQD 601_ MVQIR 606_ KSLGL 611_ CPQHD 616_ ILFDN 621_ LTVAE 626_ HLYFY 631_ AQLKG 636_ LSRQK 641_ CPEEV 646_ KQMLH 651_ IIGLE 656_ DKWNS 661_ RSRFL 666_ SGGMR 671_ RKLSI 676_ GIALI 681_ AGSKV 686_ LILDE 691_ PTSGM 696_ DAISR 701_ RAIWD 706_ LLQRQ 711_ KSDRT 716_ IVLTT 721_ HFMDE 726_ ADLLG 731_ DRIAI 736_ MAKGE 741_ LQCCG 746_ SSLFL 751_ KQKYG 756_ AGYHM 761_ TLVKE 766_ PHCNP 771_ EDISQ 776_ LVHHH 781_ VPNAT 786_ LESSA 791_ GAELS 796_ FILPR 801_ ESTHR 806_ FEGLF 811_ AKLEK 816_ KQKEL 821_ GIASF 826_ GASIT 831_ TMEEV 836_ FLRVG 841_ KLVDS 846_ SMDIQ 851_ AIQLP 856_ ALQYQ 861_ HERRA 866_ SDWAV 871_ DSNLC 876_ GAMDP 881_ SDGIG 886_ ALIEE 891_ ERTAV 896_ KLNTG 901_ LALHC 906_ QQFWA 911_ MFLKK 916_ AAYSW 921_ REWKM 926_ VAAQV 931_ LVPLT 936_ CVTLA 941_ LLAIN 946_ YSSEL 951_ FDDPM 956_ LRLTL 961_ GEYGR 966_ TVVPF 971_ SVPGT 976_ SQLGQ 981_ QLSEH 986_ LKDAL 991_ QAEGQ 996_ EPREV 1001_ LGDLE 1006_ EFLIF 1011_ RASVE 1016_ GGGFN 1021_ ERCLV 1026_ AASFR 1031_ DVGER 1036_ TVVNA 1041_ LFNNQ 1046_ AYHSP 1051_ ATALA 1056_ VVDNL 1061_ LFKLL 1066_ CGPHA 1071_ SIVVS 1076_ NFPQP 1081_ RSALQ 1086_ AAKDQ 1091_ FNEGR 1096_ KGFDI 1101_ ALNLL 1106_ FAMAF 1111_ LASTF 1116_ SILAV 1121_ SERAV 1126_ QAKHV 1131_ QFVSG 1136_ VHVAS 1141_ FWLSA 1146_ LLWDL 1151_ ISFLI 1156_ PSLLL 1161_ LVVFK 1166_ AFDVR 1171_ AFTRD 1176_ GHMAD 1181_ TLLLL 1186_ LLYGW 1191_ AIIPL 1196_ MYLMN 1201_ FFFLG 1206_ AATAY 1211_ TRLTI 1216_ FNILS 1221_ GIATF 1226_ LMVTI 1231_ MRIPA 1236_ VKLEE 1241_ LSKTL 1246_ DHVFL 1251_ VLPNH 1256_ CLGMA 1261_ VSSFY 1266_ ENYET 1271_ RRYCT 1276_ SSEVA 1281_ AHYCK 1286_ KYNIQ 1291_ YQENF 1296_ YAWSA 1301_ PGVGR 1306_ FVASM 1311_ AASGC 1316_ AYLIL 1321_ LFLIE 1326_ TNLLQ 1331_ RLRGI 1336_ LCALR 1341_ RRRTL 1346_ TELYT 1351_ RMPVL 1356_ PEDQD 1361_ VADER 1366_ TRILA 1371_ PSPDS 1376_ LLHTP 1381_ LIIKE 1386_ LSKVY 1391_ EQRVP 1396_ LLAVD 1401_ RLSLA 1406_ VQKGE 1411_ CFGLL 1416_ GFNGA 1421_ GKTTT 1426_ FKMLT 1431_ GEESL 1436_ TSGDA 1441_ FVGGH 1446_ RISSD 1451_ VGKVR 1456_ QRIGY 1461_ CPQFD 1466_ ALLDH 1471_ MTGRE 1476_ MLVMY 1481_ ARLRG 1486_ IPERH 1491_ IGACV 1496_ ENTLR 1501_ GLLLE 1506_ PHANK 1511_ LVRTY 1516_ SGGNK 1521_ RKLST 1526_ GIALI 1531_ GEPAV 1536_ IFLDE 1541_ PSTGM 1546_ DPVAR 1551_ RLLWD 1556_ TVARA 1561_ RESGK 1566_ AIIIT 1571_ SHSME 1576_ ECEAL 1581_ CTRLA 1586_ IMVQG 1591_ QFKCL 1596_ GSPQH 1601_ LKSKF 1606_ GSGYS 1611_ LRAKV 1616_ QSEGQ 1621_ QEALE 1626_ EFKAF 1631_ VDLTF 1636_ PGSVL 1641_ EDEHQ 1646_ GMVHY 1651_ HLPGR 1656_ DLSWA 1661_ KVFGI 1666_ LEKAK 1671_ EKYGV 1676_ DDYSV 1681_ SQISL 1686_ EQVFL 1691_ SFAHL 1696_QPPTA
1: Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant (PubMed:16959783, PubMed:17574245, PubMed:27177387, PubMed:28887056, PubMed:31473345). Transports preferentially phosphatidylcholine containing short acyl chains (PubMed:27177387). In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity (PubMed:25817392, PubMed:26903515, PubMed:27177387)