Chemerin-like receptor 1 (Chemokine-like receptor 1) (G-protein coupled receptor ChemR23) (G-protein coupled receptor DEZ)
1_MRMED 6_ EDYNT 11_ SISYG 16_ DEYPD 21_ YLDSI 26_ VVLED 31_ LSPLE 36_ ARVTR 41_ IFLVV 46_ VYSIV 51_ CFLGI 56_ LGNGL 61_ VIIIA 66_ TFKMK 71_ KTVNM 76_ VWFLN 81_ LAVAD 86_ FLFNV 91_ FLPIH 96_ ITYAA 101_ MDYHW 106_ VFGTA 111_ MCKIS 116_ NFLLI 121_ HNMFT 126_ SVFLL 131_ TIISS 136_ DRCIS 141_ VLLPV 146_ WSQNH 151_ RSVRL 156_ AYMAC 161_ MVIWV 166_ LAFFL 171_ SSPSL 176_ VFRDT 181_ ANLHG 186_ KISCF 191_ NNFSL 196_ STPGS 201_ SSWPT 206_ HSQMD 211_ PVGYS 216_ RHMVV 221_ TVTRF 226_ LCGFL 231_ VPVLI 236_ ITACY 241_ LTIVC 246_ KLQRN 251_ RLAKT 256_ KKPFK 261_ IIVTI 266_ IITFF 271_ LCWCP 276_ YHTLN 281_ LLELH 286_ HTAMP 291_ GSVFS 296_ LGLPL 301_ ATALA 306_ IANSC 311_ MNPIL 316_ YVFMG 321_ QDFKK 326_ FKVAL 331_ FSRLV 336_ NALSE 341_ DTGHS 346_ SYPSH 351_ RSFTK 356_ MSSMN 361_ ERTSM 366_NERET
1: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism
2: (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2)