Homeobox protein Nkx-3.1 (Homeobox protein NK-3 homolog A)
1_MLRVP 6_ EPRPG 11_ EAKAE 16_ GAAPP 21_ TPSKP 26_ LTSFL 31_ IQDIL 36_ RDGAQ 41_ RQGGR 46_ TSSQR 51_ QRDPE 56_ PEPEP 61_ EPEGG 66_ RSRAG 71_ AQNDQ 76_ LSTGP 81_ RAAPE 86_ EAETL 91_ AETEP 96_ ERHLG 101_ SYLLD 106_ SENTS 111_ GALPR 116_ LPQTP 121_ KQPQK 126_ RSRAA 131_ FSHTQ 136_ VIELE 141_ RKFSH 146_ QKYLS 151_ APERA 156_ HLAKN 161_ LKLTE 166_ TQVKI 171_ WFQNR 176_ RYKTK 181_ RKQLS 186_ SELGD 191_ LEKHS 196_ SLPAL 201_ KEEAF 206_ SRASL 211_ VSVYN 216_ SYPYY 221_ PYLYC 226_VGSWS
1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells