Equilibrative nucleoside transporter 1 (Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter) (Equilibrative NBMPR-sensitive nucleoside transporter) (Nucleoside transporter, es-type) (Solute carrier family 29 member 1)
1_MTTSH 6_ QPQDR 11_ YKAVW 16_ LIFFM 21_ LGLGT 26_ LLPWN 31_ FFMTA 36_ TQYFT 41_ NRLDM 46_ SQNVS 51_ LVTAE 56_ LSKDA 61_ QASAA 66_ PAAPL 71_ PERNS 76_ LSAIF 81_ NNVMT 86_ LCAML 91_ PLLLF 96_ TYLNS 101_ FLHQR 106_ IPQSV 111_ RILGS 116_ LVAIL 121_ LVFLI 126_ TAILV 131_ KVQLD 136_ ALPFF 141_ VITMI 146_ KIVLI 151_ NSFGA 156_ ILQGS 161_ LFGLA 166_ GLLPA 171_ SYTAP 176_ IMSGQ 181_ GLAGF 186_ FASVA 191_ MICAI 196_ ASGSE 201_ LSESA 206_ FGYFI 211_ TACAV 216_ IILTI 221_ ICYLG 226_ LPRLE 231_ FYRYY 236_ QQLKL 241_ EGPGE 246_ QETKL 251_ DLISK 256_ GEEPR 261_ AGKEE 266_ SGVSV 271_ SNSQP 276_ TNESH 281_ SIKAI 286_ LKNIS 291_ VLAFS 296_ VCFIF 301_ TITIG 306_ MFPAV 311_ TVEVK 316_ SSIAG 321_ SSTWE 326_ RYFIP 331_ VSCFL 336_ TFNIF 341_ DWLGR 346_ SLTAV 351_ FMWPG 356_ KDSRW 361_ LPSLV 366_ LARLV 371_ FVPLL 376_ LLCNI 381_ KPRRY 386_ LTVVF 391_ EHDAW 396_ FIFFM 401_ AAFAF 406_ SNGYL 411_ ASLCM 416_ CFGPK 421_ KVKPA 426_ EAETA 431_ GAIMA 436_ FFLCL 441_ GLALG 446_ AVFSF 451_LFRAI
1: Uniporter involved in the facilitative transport of nucleosides and nucleobases, and contributes to maintaining their cellular homeostasis (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:21795683, PubMed:26406980, PubMed:27995448, PubMed:35790189, PubMed:8986748). Functions as a Na(+)-independent transporter (PubMed:8986748). Involved in the transport of nucleosides such as adenosine, guanosine, inosine, uridine, thymidine and cytidine (PubMed:10722669, PubMed:10755314, PubMed:12527552, PubMed:14759222, PubMed:15037197, PubMed:17379602, PubMed:26406980, PubMed:8986748). Also transports purine nucleobases (hypoxanthine, adenine, guanine) and pyrimidine nucleobases (thymine, uracil) (PubMed:21795683, PubMed:27995448). Mediates basolateral nucleoside uptake into Sertoli cells, thereby regulating the transport of nucleosides in testis across the blood-testis barrier (By similarity). Regulates inosine levels in brown adipocytes tissues (BAT) and extracellular inosine levels, which controls BAT-dependent energy expenditure (PubMed:35790189)