Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
1_MTADK 6_ EKKRS 11_ SSERR 16_ KEKSR 21_ DAARC 26_ RRSKE 31_ TEVFY 36_ ELAHE 41_ LPLPH 46_ SVSSH 51_ LDKAS 56_ IMRLA 61_ ISFLR 66_ THKLL 71_ SSVCS 76_ ENESE 81_ AEADQ 86_ QMDNL 91_ YLKAL 96_ EGFIA 101_ VVTQD 106_ GDMIF 111_ LSENI 116_ SKFMG 121_ LTQVE 126_ LTGHS 131_ IFDFT 136_ HPCDH 141_ EEIRE 146_ NLSLK 151_ NGSGF 156_ GKKSK 161_ DMSTE 166_ RDFFM 171_ RMKCT 176_ VTNRG 181_ RTVNL 186_ KSATW 191_ KVLHC 196_ TGQVK 201_ VYNNC 206_ PPHNS 211_ LCGYK 216_ EPLLS 221_ CLIIM 226_ CEPIQ 231_ HPSHM 236_ DIPLD 241_ SKTFL 246_ SRHSM 251_ DMKFT 256_ YCDDR 261_ ITELI 266_ GYHPE 271_ ELLGR 276_ SAYEF 281_ YHALD 286_ SENMT 291_ KSHQN 296_ LCTKG 301_ QVVSG 306_ QYRML 311_ AKHGG 316_ YVWLE 321_ TQGTV 326_ IYNPR 331_ NLQPQ 336_ CIMCV 341_ NYVLS 346_ EIEKN 351_ DVVFS 356_ MDQTE 361_ SLFKP 366_ HLMAM 371_ NSIFD 376_ SSGKG 381_ AVSEK 386_ SNFLF 391_ TKLKE 396_ EPEEL 401_ AQLAP 406_ TPGDA 411_ IISLD 416_ FGNQN 421_ FEESS 426_ AYGKA 431_ ILPPS 436_ QPWAT 441_ ELRSH 446_ STQSE 451_ AGSLP 456_ AFTVP 461_ QAAAP 466_ GSTTP 471_ SATSS 476_ SSSCS 481_ TPNSP 486_ EDYYT 491_ SLDND 496_ LKIEV 501_ IEKLF 506_ AMDTE 511_ AKDQC 516_ STQTD 521_ FNELD 526_ LETLA 531_ PYIPM 536_ DGEDF 541_ QLSPI 546_ CPEER 551_ LLAEN 556_ PQSTP 561_ QHCFS 566_ AMTNI 571_ FQPLA 576_ PVAPH 581_ SPFLL 586_ DKFQQ 591_ QLESK 596_ KTEPE 601_ HRPMS 606_ SIFFD 611_ AGSKA 616_ SLPPC 621_ CGQAS 626_ TPLSS 631_ MGGRS 636_ NTQWP 641_ PDPPL 646_ HFGPT 651_ KWAVG 656_ DQRTE 661_ FLGAA 666_ PLGPP 671_ VSPPH 676_ VSTFK 681_ TRSAK 686_ GFGAR 691_ GPDVL 696_ SPAMV 701_ ALSNK 706_ LKLKR 711_ QLEYE 716_ EQAFQ 721_ DLSGG 726_ DPPGG 731_ STSHL 736_ MWKRM 741_ KNLRG 746_ GSCPL 751_ MPDKP 756_ LSANV 761_ PNDKF 766_ TQNPM 771_ RGLGH 776_ PLRHL 781_ PLPQP 786_ PSAIS 791_ PGENS 796_ KSRFP 801_ PQCYA 806_ TQYQD 811_ YSLSS 816_ AHKVS 821_ GMASR 826_ LLGPS 831_ FESYL 836_ LPELT 841_ RYDCE 846_ VNVPV 851_ LGSST 856_ LLQGG 861_DLLRA
1: Transcription factor involved in the induction of oxygen regulated genes. Heterodimerizes with ARNT; heterodimer binds to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters (By similarity). Regulates the vascular endothelial growth factor (VEGF) expression and seems to be implicated in the development of blood vessels and the tubular system of lung. May also play a role in the formation of the endothelium that gives rise to the blood brain barrier. Potent activator of the Tie-2 tyrosine kinase expression. Activation requires recruitment of transcriptional coactivators such as CREBBP and probably EP300. Interaction with redox regulatory protein APEX1 seems to activate CTAD (By similarity)