Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)
1_MAVSE 6_ SQLKK 11_ MVSKY 16_ KYRDL 21_ TVRET 26_ VNVIT 31_ LYKDL 36_ KPVLD 41_ SYVFN 46_ DGSSR 51_ ELMNL 56_ TGTIP 61_ VPYRG 66_ NTYNI 71_ PICLW 76_ LLDTY 81_ PYNPP 86_ ICFVK 91_ PTSSM 96_ TIKTG 101_ KHVDA 106_ NGKIY 111_ LPYLH 116_ EWKHP 121_ QSDLL 126_ GLIQV 131_ MIVVF 136_ GDEPP 141_ VFSRP 146_ ISASY 151_ PPYQA 156_ TGPPN 161_ TSYMP 166_ GMPGG 171_ ISPYP 176_ SGYPP 181_ NPSGY 186_ PGCPY 191_ PPGGP 196_ YPATT 201_ SSQYP 206_ SQPPV 211_ TTVGP 216_ SRDGT 221_ ISEDT 226_ IRASL 231_ ISAVS 236_ DKLRW 241_ RMKEE 246_ MDRAQ 251_ AELNA 256_ LKRTE 261_ EDLKK 266_ GHQKL 271_ EEMVT 276_ RLDQE 281_ VAEVD 286_ KNIEL 291_ LKKKD 296_ EELSS 301_ ALEKM 306_ ENQSE 311_ NNDID 316_ EVIIP 321_ TAPLY 326_ KQILN 331_ LYAEE 336_ NAIED 341_ TIFYL 346_ GEALR 351_ RGVID 356_ LDVFL 361_ KHVRL 366_ LSRKQ 371_ FQLRA 376_ LMQKA 381_RKTAG
1: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426)