Copine-1 (Chromobindin 17) (Copine I)
1_MAHCV 6_ TLVQL 11_ SISCD 16_ HLIDK 21_ DIGSK 26_ SDPLC 31_ VLLQD 36_ VGGGS 41_ WAELG 46_ RTERV 51_ RNCSS 56_ PEFSK 61_ TLQLE 66_ YRFET 71_ VQKLR 76_ FGIYD 81_ IDNKT 86_ PELRD 91_ DDFLG 96_ GAECS 101_ LGQIV 106_ SSQVL 111_ TLPLM 116_ LKPGK 121_ PAGRG 126_ TITVS 131_ AQELK 136_ DNRVV 141_ TMEVE 146_ ARNLD 151_ KKDFL 156_ GKSDP 161_ FLEFF 166_ RQGDG 171_ KWHLV 176_ YRSEV 181_ IKNNL 186_ NPTWK 191_ RFSVP 196_ VQHFC 201_ GGNPS 206_ TPIQV 211_ QCSDY 216_ DSDGS 221_ HDLIG 226_ TFHTS 231_ LAQLQ 236_ AVPAE 241_ FECIH 246_ PEKQQ 251_ KKKSY 256_ KNSGT 261_ IRVKI 266_ CRVET 271_ EYSFL 276_ DYVMG 281_ GCQIN 286_ FTVGV 291_ DFTGS 296_ NGDPS 301_ SPDSL 306_ HYLSP 311_ TGVNE 316_ YLMAL 321_ WSVGS 326_ VVQDY 331_ DSDKL 336_ FPAFG 341_ FGAQV 346_ PPDWQ 351_ VSHEF 356_ ALNFN 361_ PSNPY 366_ CAGIQ 371_ GIVDA 376_ YRQAL 381_ PQVRL 386_ YGPTN 391_ FAPII 396_ NHVAR 401_ FAAQA 406_ AHQGT 411_ ASQYF 416_ MLLLL 421_ TDGAV 426_ TDVEA 431_ TREAV 436_ VRASN 441_ LPMSV 446_ IIVGV 451_ GGADF 456_ EAMEQ 461_ LDADG 466_ GPLHT 471_ RSGQA 476_ AARDI 481_ VQFVP 486_ YRRFQ 491_ NAPRE 496_ ALAQT 501_ VLAEV 506_ PTQLV 511_ SYFRA 516_ QGWAP 521_ LKPLP 526_ PSAKD 531_PAQAP
1: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740)