Smoothened homolog (SMO) (Protein Gx)
1_MAAAR 6_ PARGP 11_ ELPLL 16_ GLLLL 21_ LLLGD 26_ PGRGA 31_ ASSGN 36_ ATGPG 41_ PRSAG 46_ GSARR 51_ SAAVT 56_ GPPPP 61_ LSHCG 66_ RAAPC 71_ EPLRY 76_ NVCLG 81_ SVLPY 86_ GATST 91_ LLAGD 96_ SDSQE 101_ EAHGK 106_ LVLWS 111_ GLRNA 116_ PRCWA 121_ VIQPL 126_ LCAVY 131_ MPKCE 136_ NDRVE 141_ LPSRT 146_ LCQAT 151_ RGPCA 156_ IVERE 161_ RGWPD 166_ FLRCT 171_ PDRFP 176_ EGCTN 181_ EVQNI 186_ KFNSS 191_ GQCEV 196_ PLVRT 201_ DNPKS 206_ WYEDV 211_ EGCGI 216_ QCQNP 221_ LFTEA 226_ EHQDM 231_ HSYIA 236_ AFGAV 241_ TGLCT 246_ LFTLA 251_ TFVAD 256_ WRNSN 261_ RYPAV 266_ ILFYV 271_ NACFF 276_ VGSIG 281_ WLAQF 286_ MDGAR 291_ REIVC 296_ RADGT 301_ MRLGE 306_ PTSNE 311_ TLSCV 316_ IIFVI 321_ VYYAL 326_ MAGVV 331_ WFVVL 336_ TYAWH 341_ TSFKA 346_ LGTTY 351_ QPLSG 356_ KTSYF 361_ HLLTW 366_ SLPFV 371_ LTVAI 376_ LAVAQ 381_ VDGDS 386_ VSGIC 391_ FVGYK 396_ NYRYR 401_ AGFVL 406_ APIGL 411_ VLIVG 416_ GYFLI 421_ RGVMT 426_ LFSIK 431_ SNHPG 436_ LLSEK 441_ AASKI 446_ NETML 451_ RLGIF 456_ GFLAF 461_ GFVLI 466_ TFSCH 471_ FYDFF 476_ NQAEW 481_ ERSFR 486_ DYVLC 491_ QANVT 496_ IGLPT 501_ KQPIP 506_ DCEIK 511_ NRPSL 516_ LVEKI 521_ NLFAM 526_ FGTGI 531_ AMSTW 536_ VWTKA 541_ TLLIW 546_ RRTWC 551_ RLTGQ 556_ SDDEP 561_ KRIKK 566_ SKMIA 571_ KAFSK 576_ RHELL 581_ QNPGQ 586_ ELSFS 591_ MHTVS 596_ HDGPV 601_ AGLAF 606_ DLNEP 611_ SADVS 616_ SAWAQ 621_ HVTKM 626_ VARRG 631_ AILPQ 636_ DISVT 641_ PVATP 646_ VPPEE 651_ QANLW 656_ LVEAE 661_ ISPEL 666_ QKRLG 671_ RKKKR 676_ RKRKK 681_ EVCPL 686_ APPPE 691_ LHPPA 696_ PAPST 701_ IPRLP 706_ QLPRQ 711_ KCLVA 716_ AGAWG 721_ AGDSC 726_ RQGAW 731_ TLVSN 736_ PFCPE 741_ PSPPQ 746_ DPFLP 751_ SAPAP 756_ VAWAH 761_ GRRQG 766_ LGPIH 771_ SRTNL 776_ MDTEL 781_MDADS
1: G protein-coupled receptor which associates with the patched protein (PTCH) to transduce hedgehog protein signaling. Binding of sonic hedgehog (SHH) to its receptor patched prevents inhibition of smoothened (SMO) by patched. When active, SMO binds to and sequesters protein kinase A catalytic subunit PRKACA at the cell membrane, preventing PRKACA-mediated phosphorylation of GLI transcription factors which releases the GLI proteins from PRKACA-mediated inhibition and allows for transcriptional activation of hedgehog pathway target genes (By similarity). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity)