Myeloid differentiation primary response protein MyD88
1_MAAGG 6_ PGAGS 11_ AAPVS 16_ STSSL 21_ PLAAL 26_ NMRVR 31_ RRLSL 36_ FLNVR 41_ TQVAA 46_ DWTAL 51_ AEEMD 56_ FEYLE 61_ IRQLE 66_ TQADP 71_ TGRLL 76_ DAWQG 81_ RPGAS 86_ VGRLL 91_ ELLTK 96_ LGRDD 101_ VLLEL 106_ GPSIE 111_ EDCQK 116_ YILKQ 121_ QQEEA 126_ EKPLQ 131_ VAAVD 136_ SSVPR 141_ TAELA 146_ GITTL 151_ DDPLG 156_ HMPER 161_ FDAFI 166_ CYCPS 171_ DIQFV 176_ QEMIR 181_ QLEQT 186_ NYRLK 191_ LCVSD 196_ RDVLP 201_ GTCVW 206_ SIASE 211_ LIEKR 216_ CRRMV 221_ VVVSD 226_ DYLQS 231_ KECDF 236_ QTKFA 241_ LSLSP 246_ GAHQK 251_ RLIPI 256_ KYKAM 261_ KKEFP 266_ SILRF 271_ ITVCD 276_ YTNPC 281_ TKSWF 286_ WTRLA 291_KALSL
1: Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response (PubMed:15361868, PubMed:18292575, PubMed:33718825, PubMed:37971847). Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15361868, PubMed:19506249, PubMed:24316379). Increases IL-8 transcription (PubMed:9013863). Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation (PubMed:33718825). MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine (By similarity)