Protein arginine N-methyltransferase 1 (EC 2.1.1.319) (Histone-arginine N-methyltransferase PRMT1) (Interferon receptor 1-bound protein 4)
1_MAAAE 6_ AANCI 11_ MENFV 16_ ATLAN 21_ GMSLQ 26_ PPLEE 31_ VSCGQ 36_ AESSE 41_ KPNAE 46_ DMTSK 51_ DYYFD 56_ SYAHF 61_ GIHEE 66_ MLKDE 71_ VRTLT 76_ YRNSM 81_ FHNRH 86_ LFKDK 91_ VVLDV 96_ GSGTG 101_ ILCMF 106_ AAKAG 111_ ARKVI 116_ GIECS 121_ SISDY 126_ AVKIV 131_ KANKL 136_ DHVVT 141_ IIKGK 146_ VEEVE 151_ LPVEK 156_ VDIII 161_ SEWMG 166_ YCLFY 171_ ESMLN 176_ TVLYA 181_ RDKWL 186_ APDGL 191_ IFPDR 196_ ATLYV 201_ TAIED 206_ RQYKD 211_ YKIHW 216_ WENVY 221_ GFDMS 226_ CIKDV 231_ AIKEP 236_ LVDVV 241_ DPKQL 246_ VTNAC 251_ LIKEV 256_ DIYTV 261_ KVEDL 266_ TFTSP 271_ FCLQV 276_ KRNDY 281_ VHALV 286_ AYFNI 291_ EFTRC 296_ HKRTG 301_ FSTSP 306_ ESPYT 311_ HWKQT 316_ VFYME 321_ DYLTV 326_ KTGEE 331_ IFGTI 336_ GMRPN 341_ AKNNR 346_ DLDFT 351_ IDLDF 356_ KGQLC 361_ ELSCS 366_TDYRM
1: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP, MAP3K5/ASK1, MICU1 and NPRL2 (PubMed:10749851, PubMed:15741314, PubMed:16879614, PubMed:18951090, PubMed:22095282, PubMed:25284789, PubMed:26575292, PubMed:26876602, PubMed:27642082, PubMed:30765518, PubMed:31257072, PubMed:38006878). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-3' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates MRE11 and TP53BP1, promoting the DNA damage response (PubMed:15741314, PubMed:16294045, PubMed:29651020). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity (PubMed:18951090). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (PubMed:22095282). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Plays a role in regulating alternative splicing in the heart (By similarity). Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions (PubMed:38006878)