Histone H2B type 1-M (Histone H2B.e) (H2B/e)
1_MPEPV 6_ KSAPV 11_ PKKGS 16_ KKAIN 21_ KAQKK 26_ DGKKR 31_ KRSRK 36_ ESYSV 41_ YVYKV 46_ LKQVH 51_ PDTGI 56_ SSKAM 61_ GIMNS 66_ FVNDI 71_ FERIA 76_ GEASR 81_ LAHYN 86_ KRSTI 91_ TSREI 96_ QTAVR 101_ LLLPG 106_ ELAKH 111_ AVSEG 116_ TKAVT 121_KYTSS
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling