Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)
1_METNE 6_ STEGS 11_ RSRSR 16_ SLDIQ 21_ PSSEG 26_ LGPTS 31_ EPFPS 36_ SDDSP 41_ RSALA 46_ AATAA 51_ AAAAA 56_ SAAAA 61_ TAAFT 66_ TAKAA 71_ ALSTK 76_ TPAPC 81_ SEFME 86_ PSSDP 91_ SLLGE 96_ PCAGP 101_ GFTHN 106_ IAHGS 111_ LGFEP 116_ VYVSC 121_ IAQDT 126_ CTTTD 131_ HSSNP 136_ GPVPG 141_ SSSGP 146_ VLGSS 151_ SGAGH 156_ GSGSG 161_ SGPGC 166_ GSVPG 171_ SGSGP 176_ GPGSG 181_ PGSGP 186_ GHGSG 191_ SHPGP 196_ ASGPG 201_ PDTGP 206_ DSELS 211_ PCIPP 216_ GFRNL 221_ VADRV 226_ PNYTS 231_ WSQHC 236_ PWEPQ 241_ KQPPW 246_ EFLQV 251_ LEPGA 256_ RGLWK 261_ PPDIK 266_ GKLMV 271_ CYETL 276_ PRGQC 281_ LLYNW 286_ EEERA 291_ TNHLD 296_ QVPSM 301_ QDGSE 306_ SFFFR 311_ HGHRG 316_ LLTMQ 321_ LKSPM 326_ PSSTT 331_ QKDSY 336_ QPPGN 341_ VYWPL 346_ RGKRE 351_ AMLEM 356_ LLQHQ 361_ ICKEV 366_ QAEQE 371_ PTRKL 376_ FEVES 381_ VTHHD 386_ YRMEL 391_ AQAGT 396_ PAPTK 401_ PHDYR 406_ QEQPE 411_ TFWIQ 416_ RAPQL 421_ PGVSN 426_ IRTLD 431_ TPFRK 436_ NCSFS 441_ TPVPL 446_ SLGKL 451_ LPYEP 456_ ENYPY 461_ QLGEI 466_ SSLPC 471_ PGGRL 476_GGGGG
1: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (PubMed:19548270). May play a role in fertility and microtubule formation through interaction with RANBP9 (PubMed:10500252)