BAG family molecular chaperone regulator 1 (BAG-1) (Bcl-2-associated athanogene 1)
1_MAQRG 6_ GARRP 11_ RGDRE 16_ RLGSR 21_ LRALR 26_ PGREP 31_ RQSEP 36_ PAQRG 41_ PPPSG 46_ RPPAR 51_ STASG 56_ HDRPT 61_ RGAAA 66_ GARRP 71_ RMKKK 76_ TRRRS 81_ TRSEE 86_ LTRSE 91_ ELTLS 96_ EEATW 101_ SEEAT 106_ QSEEA 111_ TQGEE 116_ MNRSQ 121_ EVTRD 126_ EESTR 131_ SEEVT 136_ REEMA 141_ AAGLT 146_ VTVTH 151_ SNEKH 156_ DLHVT 161_ SQQGS 166_ SEPVV 171_ QDLAQ 176_ VVEEV 181_ IGVPQ 186_ SFQKL 191_ IFKGK 196_ SLKEM 201_ ETPLS 206_ ALGIQ 211_ DGCRV 216_ MLIGK 221_ KNSPQ 226_ EEVEL 231_ KKLKH 236_ LEKSV 241_ EKIAD 246_ QLEEL 251_ NKELT 256_ GIQQG 261_ FLPKD 266_ LQAEA 271_ LCKLD 276_ RRVKA 281_ TIEQF 286_ MKILE 291_ EIDTL 296_ ILPEN 301_ FKDSR 306_ LKRKG 311_ LVKKV 316_ QAFLA 321_ ECDTV 326_ EQNIC 331_ QETER 336_LQSTN
1: Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:24318877, PubMed:27474739, PubMed:9873016). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631). Involved in the STUB1-mediated proteasomal degradation of ESR1 in response to age-related circulating estradiol (17-beta-estradiol/E2) decline, thereby promotes neuronal apoptosis in response to ischemic reperfusion injury (By similarity)