Opiorphin prepropeptide (Basic proline-rich lacrimal protein) (Proline-rich protein 1) (PRL1) [Cleaved into: Opiorphin]
1_MKLTF 6_ FLGLL 11_ ALISC 16_ FTPSE 21_ SQRFS 26_ RRPYL 31_ PGQLP 36_ PPPLY 41_ RPRWV 46_ PPSPP 51_ PPYDS 56_ RLNSP 61_ LSLPF 66_ VPGRV 71_ PPSSF 76_ SRFSQ 81_ AVILS 86_ QLFPL 91_ ESIRQ 96_ PRLFP 101_ GYPNL 106_ HFPLR 111_ PYYVG 116_ PIRIL 121_ KPPFP 126_ PIPFF 131_ LAIYL 136_ PISNP 141_ EPQIN 146_ ITTAD 151_ TTITT 156_ NPPTT 161_ ATATT 166_ STSTK 171_ PTMTI 176_ SSSTV 181_ PISST 186_ PEPAT 191_ SISAA 196_ TPAAS 201_ TENTT 206_ QILAN 211_ RPHTV 216_ LLNAT 221_ VQVTT 226_ SNQTI 231_ LSSPA 236_ FKSFW 241_QKLFA
1: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection