Gene name: ATF6B

Uniprot entry:

Q99941

Protein names:

Cyclic AMP-dependent transcription factor ATF-6 beta (cAMP-dependent transcription factor ATF-6 beta) (Activating transcription factor 6 beta) (ATF6-beta) (Protein G13) (cAMP response element-binding protein-related protein) (Creb-rp) (cAMP-responsive element-binding protein-like 1) [Cleaved into: Processed cyclic AMP-dependent transcription factor ATF-6 beta]

Protein sequence:

1_MAELM 6_ LLSEI 11_ ADPTR 16_ FFTDN 21_ LLSPE 26_ DWGLQ 31_ NSTLY 36_ SGLDE 41_ VAEEQ 46_ TQLFR 51_ CPEQD 56_ VPFDG 61_ SSLDV 66_ GMDVS 71_ PSEPP 76_ WELLP 81_ IFPDL 86_ QVKSE 91_ PSSPC 96_ SSSSL 101_ SSESS 106_ RLSTE 111_ PSSEA 116_ LGVGE 121_ VLHVK 126_ TESLA 131_ PPLCL 136_ LGDDP 141_ TSSFE 146_ TVQIN 151_ VIPTS 156_ DDSSD 161_ VQTKI 166_ EPVSP 171_ CSSVN 176_ SEASL 181_ LSADS 186_ SSQAF 191_ IGEEV 196_ LEVKT 201_ ESLSP 206_ SGCLL 211_ WDVPA 216_ PSLGA 221_ VQISM 226_ GPSLD 231_ GSSGK 236_ ALPTR 241_ KPPLQ 246_ PKPVV 251_ LTTVP 256_ MPSRA 261_ VPPST 266_ TVLLQ 271_ SLVQP 276_ PPVSP 281_ VVLIQ 286_ GAIRV 291_ QPEGP 296_ APSLP 301_ RPERK 306_ SIVPA 311_ PMPGN 316_ SCPPE 321_ VDAKL 326_ LKRQQ 331_ RMIKN 336_ RESAC 341_ QSRRK 346_ KKEYL 351_ QGLEA 356_ RLQAV 361_ LADNQ 366_ QLRRE 371_ NAALR 376_ RRLEA 381_ LLAEN 386_ SELKL 391_ GSGNR 396_ KVVCI 401_ MVFLL 406_ FIAFN 411_ FGPVS 416_ ISEPP 421_ SAPIS 426_ PRMNK 431_ GEPQP 436_ RRHLL 441_ GFSEQ 446_ EPVQG 451_ VEPLQ 456_ GSSQG 461_ PKEPQ 466_ PSPTD 471_ QPSFS 476_ NLTAF 481_ PGGAK 486_ ELLLR 491_ DLDQL 496_ FLSSD 501_ CRHFN 506_ RTESL 511_ RLADE 516_ LSGWV 521_ QRHQR 526_ GRRKI 531_ PQRAQ 536_ ERQKS 541_ QPRKK 546_ SPPVK 551_ AVPIQ 556_ PPGPP 561_ ERDSV 566_ GQLQL 571_ YRHPD 576_ RSQPA 581_ FLDAI 586_ DRRED 591_ TFYVV 596_ SFRRD 601_ HLLLP 606_ AISHN 611_ KTSRP 616_ KMSLV 621_ MPAMA 626_ PNETL 631_ SGRGA 636_ PGDYE 641_ EMMQI 646_ ECEVM 651_ DTRVI 656_ HIKTS 661_ TVPPS 666_ LRKQP 671_ SPTPG 676_ NATGG 681_ PLPVS 686_ AASQA 691_ HQASH 696_QPLYL

Protein annotations

Protein functions:

1: Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944)

2: Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944)