E3 ubiquitin-protein ligase RNF5 (EC 2.3.2.27) (RING finger protein 5) (Ram1 homolog) (HsRma1)
1_MAAAE 6_ EEDGG 11_ PEGPN 16_ RERGG 21_ AGATF 26_ ECNIC 31_ LETAR 36_ EAVVS 41_ VCGHL 46_ YCWPC 51_ LHQWL 56_ ETRPE 61_ RQECP 66_ VCKAG 71_ ISREK 76_ VVPLY 81_ GRGSQ 86_ KPQDP 91_ RLKTP 96_ PRPQG 101_ QRPAP 106_ ESRGG 111_ FQPFG 116_ DTGGF 121_ HFSFG 126_ VGAFP 131_ FGFFT 136_ TVFNA 141_ HEPFR 146_ RGTGV 151_ DLGQG 156_ HPASS 161_ WQDSL 166_ FLFLA 171_IFFFF
1: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:11329381, PubMed:12861019, PubMed:16176924, PubMed:19269966, PubMed:19285439). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (PubMed:11329381). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (PubMed:12861019). Catalyzes ubiquitination of Salmonella type III secreted protein sopA (PubMed:16176924). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (PubMed:19269966). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (PubMed:19285439). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945)