Proline-rich transmembrane protein 1 (Dispanin subfamily D member 1) (DSPD1) (Synapse differentiation-induced protein 4) (SynDIG4)
1_MSSEK 6_ SGLPD 11_ SVPHT 16_ SPPPY 21_ NAPQP 26_ PAEPP 31_ APPPQ 36_ AAPSS 41_ HHHHH 46_ HHYHQ 51_ SGTAT 56_ LPRLG 61_ AGGLA 66_ SSAAT 71_ AQRGP 76_ SSSAT 81_ LPRPP 86_ HHAPP 91_ GPAAG 96_ APPPG 101_ CATLP 106_ RMPPD 111_ PYLQE 116_ TRFEG 121_ PLPPP 126_ PPAAA 131_ APPPP 136_ APAQT 141_ AQAPG 146_ FVVPT 151_ HAGTV 156_ GTLPL 161_ GGYVA 166_ PGYPL 171_ QLQPC 176_ TAYVP 181_ VYPVG 186_ TPYAG 191_ GTPGG 196_ TGVTS 201_ TLPPP 206_ PQGPG 211_ LALLE 216_ PRRPP 221_ HDYMP 226_ IAVLT 231_ TICCF 236_ WPTGI 241_ IAIFK 246_ AVQVR 251_ TALAR 256_ GDMVS 261_ AEIAS 266_ REARN 271_ FSFIS 276_ LAVGI 281_ AAMVL 286_ CTILT 291_ VVIII 296_ AAQHH 301_ENYWD
1: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function. Regulates basal AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses. Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression