Plakophilin-2
1_MAAPG 6_ APAEY 11_ GYIRT 16_ VLGQQ 21_ ILGQL 26_ DSSSL 31_ ALPSE 36_ AKLKL 41_ AGSSG 46_ RGGQT 51_ VKSLR 56_ IQEQV 61_ QQTLA 66_ RKGRS 71_ SVGNG 76_ NLHRT 81_ SSVPE 86_ YVYNL 91_ HLVEN 96_ DFVGG 101_ RSPVP 106_ KTYDM 111_ LKAGT 116_ TATYE 121_ GRWGR 126_ GTAQY 131_ SSQKS 136_ VEERS 141_ LRHPL 146_ RRLEI 151_ SPDSS 156_ PERAH 161_ YTHSD 166_ YQYSQ 171_ RSQAG 176_ HTLHH 181_ QESRR 186_ AALLV 191_ PPRYA 196_ RSEIV 201_ GVSRA 206_ GTTSR 211_ QRHFD 216_ TYHRQ 221_ YQHGS 226_ VSDTV 231_ FDSIP 236_ ANPAL 241_ LTYPR 246_ PGTSR 251_ SMGNL 256_ LEKEN 261_ YLTAG 266_ LTVGQ 271_ VRPLV 276_ PLQPV 281_ TQNRA 286_ SRSSW 291_ HQSSF 296_ HSTRT 301_ LREAG 306_ PSVAV 311_ DSSGR 316_ RAHLT 321_ VGQAA 326_ AGGSG 331_ NLLTE 336_ RSTFT 341_ DSQLG 346_ NADME 351_ MTLER 356_ AVSML 361_ EADHM 366_ LPSRI 371_ SAAAT 376_ FIQHE 381_ CFQKS 386_ EARKR 391_ VNQLR 396_ GILKL 401_ LQLLK 406_ VQNED 411_ VQRAV 416_ CGALR 421_ NLVFE 426_ DNDNK 431_ LEVAE 436_ LNGVP 441_ RLLQV 446_ LKQTR 451_ DLETK 456_ KQITD 461_ HTVNL 466_ RSRNG 471_ WPGAV 476_ AHACN 481_ PSTLG 486_ GQGGR 491_ ITRSG 496_ VRDQP 501_ DQHGL 506_ LWNLS 511_ SNDKL 516_ KNLMI 521_ TEALL 526_ TLTEN 531_ IIIPF 536_ SGWPE 541_ GDYPK 546_ ANGLL 551_ DFDIF 556_ YNVTG 561_ CLRNM 566_ SSAGA 571_ DGRKA 576_ MRRCD 581_ GLIDS 586_ LVHYV 591_ RGTIA 596_ DYQPD 601_ DKATE 606_ NCVCI 611_ LHNLS 616_ YQLEA 621_ ELPEK 626_ YSQNI 631_ YIQNR 636_ NIQTD 641_ NNKSI 646_ GCFGS 651_ RSRKV 656_ KEQYQ 661_ DVPMP 666_ EEKSN 671_ PKGVE 676_ WLWHS 681_ IVIRM 686_ YLSLI 691_ AKSVR 696_ NYTQE 701_ ASLGA 706_ LQNLT 711_ AGSGP 716_ MPTSV 721_ AQTVV 726_ QKESG 731_ LQHTR 736_ KMLHV 741_ GDPSV 746_ KKTAI 751_ SLLRN 756_ LSRNL 761_ SLQNE 766_ IAKET 771_ LPDLV 776_ SIIPD 781_ TVPST 786_ DLLIE 791_ TTASA 796_ CYTLN 801_ NIIQN 806_ SYQNA 811_ RDLLN 816_ TGGIQ 821_ KIMAI 826_ SAGDA 831_ YASNK 836_ ASKAA 841_ SVLLY 846_ SLWAH 851_ TELHH 856_ AYKKA 861_ QFKKT 866_ DFVNS 871_ RTAKA 876_YHSLK
1: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:25208567). Regulates focal adhesion turnover resulting in changes in focal adhesion size, cell adhesion and cell spreading, potentially via transcriptional modulation of beta-integrins (PubMed:23884246). Required to maintain gingival epithelial barrier function (PubMed:34368962). Important component of the desmosome that is also required for localization of desmosome component proteins such as DSC2, DSG2 and JUP to the desmosome cell-cell junction (PubMed:22781308, PubMed:25208567). Required for the formation of desmosome cell junctions in cardiomyocytes, thereby required for the correct formation of the heart, specifically trabeculation and formation of the atria walls (By similarity). Loss of desmosome cell junctions leads to mis-localization of DSP and DSG2 resulting in disruption of cell-cell adhesion and disordered intermediate filaments (By similarity). Modulates profibrotic gene expression in cardiomyocytes via regulation of DSP expression and subsequent activation of downstream TGFB1 and MAPK14/p38 MAPK signaling (By similarity). Required for cardiac sodium current propagation and electrical synchrony in cardiac myocytes, via ANK3 stabilization and modulation of SCN5A/Nav1.5 localization to cell-cell junctions (By similarity). Required for mitochondrial function, nuclear envelope integrity and positive regulation of SIRT3 transcription via maintaining DES localization at its nuclear envelope and cell tip anchoring points, and thereby preserving regulation of the transcriptional program (PubMed:35959657). Maintenance of nuclear envelope integrity protects against DNA damage and transcriptional dysregulation of genes, especially those involved in the electron transport chain, thereby preserving mitochondrial function and protecting against superoxide radical anion generation (PubMed:35959657). Binds single-stranded DNA (ssDNA) (PubMed:20613778). May regulate the localization of GJA1 to gap junctions in intercalated disks of the heart (PubMed:18662195). Involved in the inhibition of viral infection by influenza A viruses (IAV) (PubMed:28169297). Acts as a host restriction factor for IAV viral propagation, potentially via disrupting the interaction of IAV polymerase complex proteins (PubMed:28169297)