Cbp/p300-interacting transactivator 1 (Melanocyte-specific protein 1)
1_MPTTS 6_ RPALD 11_ VKGGT 16_ SPAKE 21_ DANQE 26_ MSSVA 31_ YSNLA 36_ VKDRK 41_ AVAIL 46_ HYPGV 51_ ASNGT 56_ KASGA 61_ PTSSS 66_ GSPIG 71_ SPTTT 76_ PPTKP 81_ PSFNL 86_ HPAPH 91_ LLASM 96_ HLQKL 101_ NSQYQ 106_ GMAAA 111_ TPGQP 116_ GEAGP 121_ LQNWD 126_ FGAQA 131_ GGAES 136_ LSPSA 141_ GAQSP 146_ AIIDS 151_ DPVDE 156_ EVLMS 161_ LVVEL 166_ GLDRA 171_ NELPE 176_ LWLGQ 181_ NEFDF 186_TADFP
1: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner