Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj)
1_MADHM 6_ MAMNH 11_ GRFPD 16_ GTNGL 21_ HHHPA 26_ HRMGM 31_ GQFPS 36_ PHHHQ 41_ QQQPQ 46_ HAFNA 51_ LMGEH 56_ IHYGA 61_ GNMNA 66_ TSGIR 71_ HAMGP 76_ GTVNG 81_ GHPPS 86_ ALAPA 91_ ARFNN 96_ SQFMG 101_ PPVAS 106_ QGGSL 111_ PASMQ 116_ LQKLN 121_ NQYFN 126_ HHPYP 131_ HNHYM 136_ PDLHP 141_ AAGHQ 146_ MNGTN 151_ QHFRD 156_ CNPKH 161_ SGGSS 166_ TPGGS 171_ GGSST 176_ PGGSG 181_ SSSGG 186_ GAGSS 191_ NSGGG 196_ SGSGN 201_ MPASV 206_ AHVPA 211_ AMLPP 216_ NVIDT 221_ DFIDE 226_ EVLMS 231_ LVIEM 236_ GLDRI 241_ KELPE 246_ LWLGQ 251_ NEFDF 256_ MTDFV 261_CKQQP
1: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region