Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
1_MRFFC 6_ ARCCS 11_ FGPEM 16_ PAVQL 21_ LLLAC 26_ LVWDV 31_ GARTA 36_ QLRKA 41_ NDQSG 46_ RCQYT 51_ FSVAS 56_ PNESS 61_ CPEQS 66_ QAMSV 71_ IHNLQ 76_ RDSST 81_ QRLDL 86_ EATKA 91_ RLSSL 96_ ESLLH 101_ QLTLD 106_ QAARP 111_ QETQE 116_ GLQRE 121_ LGTLR 126_ RERDQ 131_ LETQT 136_ RELET 141_ AYSNL 146_ LRDKS 151_ VLEEE 156_ KKRLR 161_ QENEN 166_ LARRL 171_ ESSSQ 176_ EVARL 181_ RRGQC 186_ PQTRD 191_ TARAV 196_ PPGSR 201_ EVSTW 206_ NLDTL 211_ AFQEL 216_ KSELT 221_ EVPAS 226_ RILKE 231_ SPSGY 236_ LRSGE 241_ GDTGC 246_ GELVW 251_ VGEPL 256_ TLRTA 261_ ETITG 266_ KYGVW 271_ MRDPK 276_ PTYPY 281_ TQETT 286_ WRIDT 291_ VGTDV 296_ RQVFE 301_ YDLIS 306_ QFMQG 311_ YPSKV 316_ HILPR 321_ PLEST 326_ GAVVY 331_ SGSLY 336_ FQGAE 341_ SRTVI 346_ RYELN 351_ TETVK 356_ AEKEI 361_ PGAGY 366_ HGQFP 371_ YSWGG 376_ YTDID 381_ LAVDE 386_ AGLWV 391_ IYSTD 396_ EAKGA 401_ IVLSK 406_ LNPEN 411_ LELEQ 416_ TWETN 421_ IRKQS 426_ VANAF 431_ IICGT 436_ LYTVS 441_ SYTSA 446_ DATVN 451_ FAYDT 456_ GTGIS 461_ KTLTI 466_ PFKNR 471_ YKYSS 476_ MIDYN 481_ PLEKK 486_ LFAWD 491_ NLNMV 496_TYDIK
1: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork