Serine/threonine-protein kinase VRK1 (EC 2.7.11.1) (Vaccinia-related kinase 1)
1_MPRVK 6_ AAQAG 11_ RQSSA 16_ KRHLA 21_ EQFAV 26_ GEIIT 31_ DMAKK 36_ EWKVG 41_ LPIGQ 46_ GGFGC 51_ IYLAD 56_ MNSSE 61_ SVGSD 66_ APCVV 71_ KVEPS 76_ DNGPL 81_ FTELK 86_ FYQRA 91_ AKPEQ 96_ IQKWI 101_ RTRKL 106_ KYLGV 111_ PKYWG 116_ SGLHD 121_ KNGKS 126_ YRFMI 131_ MDRFG 136_ SDLQK 141_ IYEAN 146_ AKRFS 151_ RKTVL 156_ QLSLR 161_ ILDIL 166_ EYIHE 171_ HEYVH 176_ GDIKA 181_ SNLLL 186_ NYKNP 191_ DQVYL 196_ VDYGL 201_ AYRYC 206_ PEGVH 211_ KEYKE 216_ DPKRC 221_ HDGTI 226_ EFTSI 231_ DAHNG 236_ VAPSR 241_ RGDLE 246_ ILGYC 251_ MIQWL 256_ TGHLP 261_ WEDNL 266_ KDPKY 271_ VRDSK 276_ IRYRE 281_ NIASL 286_ MDKCF 291_ PEKNK 296_ PGEIA 301_ KYMET 306_ VKLLD 311_ YTEKP 316_ LYENL 321_ RDILL 326_ QGLKA 331_ IGSKD 336_ DGKLD 341_ LSVVE 346_ NGGLK 351_ AKTIT 356_ KKRKK 361_ EIEES 366_ KEPGV 371_ EDTEW 376_ SNTQT 381_ EEAIQ 386_ TRSRT 391_RKRVQ
1: Serine/threonine kinase involved in the regulation of key cellular processes including the cell cycle, nuclear condensation, transcription regulation, and DNA damage response (PubMed:14645249, PubMed:18617507, PubMed:19103756, PubMed:33076429). Controls chromatin organization and remodeling by mediating phosphorylation of histone H3 on 'Thr-4' and histone H2AX (H2aXT4ph) (PubMed:31527692, PubMed:37179361). It also phosphorylates KAT5 in response to DNA damage, promoting KAT5 association with chromatin and histone acetyltransferase activity (PubMed:33076429). Is involved in the regulation of cell cycle progression of neural progenitors, and is required for proper cortical neuronal migration (By similarity). Is involved in neurite elongation and branching in motor neurons, and has an essential role in Cajal bodies assembly, acting through COIL phosphorylation and the control of coilin degradation (PubMed:21920476, PubMed:31090908, PubMed:31527692). Involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, it is required to induce Golgi fragmentation (PubMed:19103756). Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm (PubMed:16495336). Phosphorylates TP53BP1 and p53/TP53 on 'Thr-18', preventing the interaction between p53/TP53 and MDM2 (PubMed:10951572, PubMed:31527692). Phosphorylates ATF2 which activates its transcriptional activity (PubMed:15105425). Phosphorylates JUN (PubMed:31527692)