Dehydrogenase/reductase SDR family member 9 (EC 1.1.1.209) (EC 1.1.1.53) (3-alpha hydroxysteroid dehydrogenase) (3-alpha-HSD) (NADP-dependent retinol dehydrogenase/reductase) (RDH-E2) (RDHL) (Retinol dehydrogenase 15) (EC 1.1.1.105) (Short chain dehydrogenase/reductase family 9C member 4) (Short-chain dehydrogenase/reductase retSDR8) (Tracheobronchial epithelial cell-specific retinol dehydrogenase) (RDH-TBE)
1_MLFWV 6_ LGLLI 11_ LCGFL 16_ WTRKG 21_ KLKIE 26_ DITDK 31_ YIFIT 36_ GCDSG 41_ FGNLA 46_ ARTFD 51_ KKGFH 56_ VIAAC 61_ LTESG 66_ STALK 71_ AETSE 76_ RLRTV 81_ LLDVT 86_ DPENV 91_ KRTAQ 96_ WVKNQ 101_ VGEKG 106_ LWGLI 111_ NNAGV 116_ PGVLA 121_ PTDWL 126_ TLEDY 131_ REPIE 136_ VNLFG 141_ LISVT 146_ LNMLP 151_ LVKKA 156_ QGRVI 161_ NVSSV 166_ GGRLA 171_ IVGGG 176_ YTPSK 181_ YAVEG 186_ FNDSL 191_ RRDMK 196_ AFGVH 201_ VSCIE 206_ PGLFK 211_ TNLAD 216_ PVKVI 221_ EKKLA 226_ IWEQL 231_ SPDIK 236_ QQYGE 241_ GYIEK 246_ SLDKL 251_ KGNKS 256_ YVNMD 261_ LSPVV 266_ ECMDH 271_ ALTSL 276_ FPKTH 281_ YAAGK 286_ DAKIF 291_ WIPLS 296_ HMPAA 301_ LQDFL 306_ LLKQK 311_AELAN
1: 3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH