17-beta-hydroxysteroid dehydrogenase 14 (17-beta-HSD 14) (EC 1.1.1.62) (17-beta-hydroxysteroid dehydrogenase DHRS10) (Dehydrogenase/reductase SDR family member 10) (Retinal short-chain dehydrogenase/reductase retSDR3) (Short chain dehydrogenase/reductase family 47C member 1)
1_MATGT 6_ RYAGK 11_ VVVVT 16_ GGGRG 21_ IGAGI 26_ VRAFV 31_ NSGAR 36_ VVICD 41_ KDESG 46_ GRALE 51_ QELPG 56_ AVFIL 61_ CDVTQ 66_ EDDVK 71_ TLVSE 76_ TIRRF 81_ GRLDC 86_ VVNNA 91_ GHHPP 96_ PQRPE 101_ ETSAQ 106_ GFRQL 111_ LELNL 116_ LGTYT 121_ LTKLA 126_ LPYLR 131_ KSQGN 136_ VINIS 141_ SLVGA 146_ IGQAQ 151_ AVPYV 156_ ATKGA 161_ VTAMT 166_ KALAL 171_ DESPY 176_ GVRVN 181_ CISPG 186_ NIWTP 191_ LWEEL 196_ AALMP 201_ DPRAT 206_ IREGM 211_ LAQPL 216_ GRMGQ 221_ PAEVG 226_ AAAVF 231_ LASEA 236_ NFCTG 241_ IELLV 246_ TGGAE 251_ LGYGC 256_ KASRS 261_TPVDA
1: Catalyzes the NAD(+)-dependent oxidation of L-fucose, yielding L-fucono-1,5-lactone, which rapidly converts spontaneously to L-fucone-1,4-lactone. Can also act on D-arabinose and L-galactose, with lower catalytic efficiency (PubMed:38944119). Does not use NADPH (PubMed:38944119). May be the initial enzyme of the L-fucose degradation pathway in mammals (PubMed:17067289, PubMed:38944119)