Polyadenylate-binding protein-interacting protein 2 (PABP-interacting protein 2) (PAIP-2) (Poly(A)-binding protein-interacting protein 2)
1_MKDPS 6_ RSSTS 11_ PSIIN 16_ EDVII 21_ NGHSH 26_ EDDNP 31_ FAEYM 36_ WMENE 41_ EEFNR 46_ QIEEE 51_ LWEEE 56_ FIERC 61_ FQEML 66_ EEEEE 71_ HEWFI 76_ PARDL 81_ PQTMD 86_ QIQDQ 91_ FNDLV 96_ ISDGS 101_ SLEDL 106_ VVKSN 111_ LNPNA 116_ KEFVP 121_GVKYG
1: Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization