SOSS complex subunit B1 (Nucleic acid-binding protein 2) (Oligonucleotide/oligosaccharide-binding fold-containing protein 2B) (Sensor of single-strand DNA complex subunit B1) (Sensor of ssDNA subunit B1) (SOSS-B1) (Single-stranded DNA-binding protein 1) (hSSB1)
1_MTTET 6_ FVKDI 11_ KPGLK 16_ NLNLI 21_ FIVLE 26_ TGRVT 31_ KTKDG 36_ HEVRT 41_ CKVAD 46_ KTGSI 51_ NISVW 56_ DDVGN 61_ LIQPG 66_ DIIRL 71_ TKGYA 76_ SVFKG 81_ CLTLY 86_ TGRGG 91_ DLQKI 96_ GEFCM 101_ VYSEV 106_ PNFSE 111_ PNPEY 116_ STQQA 121_ PNKAV 126_ QNDSN 131_ PSASQ 136_ PTTGP 141_ SAASP 146_ ASENQ 151_ NGNGL 156_ SAPPG 161_ PGGGP 166_ HPPHT 171_ PSHPP 176_ STRIT 181_ RSQPN 186_ HTPAG 191_ PPGPS 196_ SNPVS 201_ NGKET 206_RRSSK
1: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint (PubMed:25249620). In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways