ATP-dependent RNA helicase DDX50 (EC 3.6.4.13) (DEAD box protein 50) (Gu-beta) (Nucleolar protein Gu2)
1_MPGKL 6_ LWGDI 11_ MELEA 16_ PLEES 21_ ESQKK 26_ ERQKS 31_ DRRKS 36_ RHHYD 41_ SDEKS 46_ ETREN 51_ GVTDD 56_ LDAPK 61_ AKKSK 66_ MKEKL 71_ NGDTE 76_ EGFNR 81_ LSDEF 86_ SKSHK 91_ SRRKD 96_ LPNGD 101_ IDEYE 106_ KKSKR 111_ VSSLD 116_ TSTHK 121_ SSDNK 126_ LEETL 131_ TREQK 136_ EGAFS 141_ NFPIS 146_ EETIK 151_ LLKGR 156_ GVTYL 161_ FPIQV 166_ KTFGP 171_ VYEGK 176_ DLIAQ 181_ ARTGT 186_ GKTFS 191_ FAIPL 196_ IERLQ 201_ RNQET 206_ IKKSR 211_ SPKVL 216_ VLAPT 221_ RELAN 226_ QVAKD 231_ FKDIT 236_ RKLSV 241_ ACFYG 246_ GTSYQ 251_ SQINH 256_ IRNGI 261_ DILVG 266_ TPGRI 271_ KDHLQ 276_ SGRLD 281_ LSKLR 286_ HVVLD 291_ EVDQM 296_ LDLGF 301_ AEQVE 306_ DIIHE 311_ SYKTD 316_ SEDNP 321_ QTLLF 326_ SATCP 331_ QWVYK 336_ VAKKY 341_ MKSRY 346_ EQVDL 351_ VGKMT 356_ QKAAT 361_ TVEHL 366_ AIQCH 371_ WSQRP 376_ AVIGD 381_ VLQVY 386_ SGSEG 391_ RAIIF 396_ CETKK 401_ NVTEM 406_ AMNPH 411_ IKQNA 416_ QCLHG 421_ DIAQS 426_ QREIT 431_ LKGFR 436_ EGSFK 441_ VLVAT 446_ NVAAR 451_ GLDIP 456_ EVDLV 461_ IQSSP 466_ PQDVE 471_ SYIHR 476_ SGRTG 481_ RAGRT 486_ GICIC 491_ FYQPR 496_ ERGQL 501_ RYVEQ 506_ KAGIT 511_ FKRVG 516_ VPSTM 521_ DLVKS 526_ KSMDA 531_ IRSLA 536_ SVSYA 541_ AVDFF 546_ RPSAQ 551_ RLIEE 556_ KGAVD 561_ ALAAA 566_ LAHIS 571_ GASSF 576_ EPRSL 581_ ITSDK 586_ GFVTM 591_ TLESL 596_ EEIQD 601_ VSCAW 606_ KELNR 611_ KLSSN 616_ AVSQI 621_ TRMCL 626_ LKGNM 631_ GVCFD 636_ VPTTE 641_ SERLQ 646_ AEWHD 651_ SDWIL 656_ SVPAK 661_ LPEIE 666_ EYYDG 671_ NTSSN 676_ SRQRS 681_ GWSSG 686_ RSGRS 691_ GRSGG 696_ RSGGR 701_ SGRQS 706_ RQGSR 711_ SGSRQ 716_ DGRRR 721_ SGNRN 726_ RSRSG 731_GHKRS
1: ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908)