U6 snRNA phosphodiesterase 1 (hUsb1) (3'-5' RNA exonuclease USB1) (EC 4.6.1.-) (Mutated in poikiloderma with neutropenia protein 1) (Mutated in PN protein 1) (hMpn1)
1_MSAAP 6_ LVGYS 11_ SSGSE 16_ DESED 21_ GMRTR 26_ PGDGS 31_ HRRGQ 36_ SPLPR 41_ QRFPV 46_ PDSVL 51_ NMFPG 56_ TEEGP 61_ EDDST 66_ KHGGR 71_ VRTFP 76_ HERGN 81_ WATHV 86_ YVPYE 91_ AKEEF 96_ LDLLD 101_ VLLPH 106_ AQTYV 111_ PRLVR 116_ MKVFH 121_ LSLSQ 126_ SVVLR 131_ HHWIL 136_ PFVQA 141_ LKARM 146_ TSFHR 151_ FFFTA 156_ NQVKI 161_ YTNQE 166_ KTRTF 171_ IGLEV 176_ TSGHA 181_ QFLDL 186_ VSEVD 191_ RVMEE 196_ FNLTT 201_ FYQDP 206_ SFHLS 211_ LAWCV 216_ GDARL 221_ QLEGQ 226_ CLQEL 231_ QAIVD 236_ GFEDA 241_ EVLLR 246_ VHTEQ 251_ VRCKS 256_GNKFF
1: 3'-5' RNA exonuclease that trims the 3' end of oligo(U) and oligo(A) tracts of the pre-U6 small nuclear RNA (snRNA) molecule, leading to the formation of a mature U6 snRNA 3' end-terminated with a 2',3'-cyclic phosphate (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). Participates in the U6 snRNA 3' end processing that prevents U6 snRNA degradation (PubMed:22899009, PubMed:23022480, PubMed:23190533, PubMed:26213367, PubMed:28887445, PubMed:30215753, PubMed:31832688). In addition also removes uridines from the 3' end of U6atac snRNA and possibly the vault RNA VTRNA1-1 (PubMed:26213367)