ADP-ribose glycohydrolase MACROD1 (MACRO domain-containing protein 1) (O-acetyl-ADP-ribose deacetylase MACROD1) (EC 3.1.1.106) (Protein LRP16) ([Protein ADP-ribosylaspartate] hydrolase MACROD1) (EC 3.2.2.-) ([Protein ADP-ribosylglutamate] hydrolase MACROD1) (EC 3.2.2.-)
1_MSLQS 6_ RLSGR 11_ LAQLR 16_ AAGQL 21_ LVPPR 26_ PRPGH 31_ LAGAT 36_ RTRSS 41_ TCGPP 46_ AFLGV 51_ FGRRA 56_ RTSAG 61_ VGAWG 66_ AAAVG 71_ RTAGV 76_ RTWAP 81_ LAMAA 86_ KVDLS 91_ TSTDW 96_ KEAKS 101_ FLKGL 106_ SDKQR 111_ EEHYF 116_ CKDFV 121_ RLKKI 126_ PTWKE 131_ MAKGV 136_ AVKVE 141_ EPRYK 146_ KDKQL 151_ NEKIS 156_ LLRSD 161_ ITKLE 166_ VDAIV 171_ NAANS 176_ SLLGG 181_ GGVDG 186_ CIHRA 191_ AGPLL 196_ TDECR 201_ TLQSC 206_ KTGKA 211_ KITGG 216_ YRLPA 221_ KYVIH 226_ TVGPI 231_ AYGEP 236_ SASQA 241_ AELRS 246_ CYLSS 251_ LDLLL 256_ EHRLR 261_ SVAFP 266_ CISTG 271_ VFGYP 276_ CEAAA 281_ EIVLA 286_ TLREW 291_ LEQHK 296_ DKVDR 301_ LIICV 306_ FLEKD 311_ EDIYR 316_SRLPH
1: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104)