Kelch domain-containing protein 3 (Testis intracellular mediator protein)
1_MLRWT 6_ VHLEG 11_ GPRRV 16_ NHAAV 21_ AVGHR 26_ VYSFG 31_ GYCSG 36_ EDYET 41_ LRQID 46_ VHIFN 51_ AVSLR 56_ WTKLP 61_ PVKSA 66_ IRGQA 71_ PVVPY 76_ MRYGH 81_ STVLI 86_ DDTVL 91_ LWGGR 96_ NDTEG 101_ ACNVL 106_ YAFDV 111_ NTHKW 116_ FTPRV 121_ SGTVP 126_ GARDG 131_ HSACV 136_ LGKIM 141_ YIFGG 146_ YEQQA 151_ DCFSN 156_ DIHKL 161_ DTSTM 166_ TWTLI 171_ CTKGS 176_ PARWR 181_ DFHSA 186_ TMLGS 191_ HMYVF 196_ GGRAD 201_ RFGPF 206_ HSNNE 211_ IYCNR 216_ IRVFD 221_ TRTEA 226_ WLDCP 231_ PTPVL 236_ PEGRR 241_ SHSAF 246_ GYNGE 251_ LYIFG 256_ GYNAR 261_ LNRHF 266_ HDLWK 271_ FNPVS 276_ FTWKK 281_ IEPKG 286_ KGPCP 291_ RRRQC 296_ CCIVG 301_ DKIVL 306_ FGGTS 311_ PSPEE 316_ GLGDE 321_ FDLID 326_ HSDLH 331_ ILDFS 336_ PSLKT 341_ LCKLA 346_ VIQYN 351_ LDQSC 356_ LPHDI 361_ RWELN 366_ AMTTN 371_ SNISR 376_PIVSS
1: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29775578, PubMed:29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:29775578, PubMed:29779948). The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation: recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons (PubMed:29775578, PubMed:29779948). The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (PubMed:26138980). May be involved in meiotic recombination process (PubMed:12606021)