Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (Protein SITPEC)
1_MSWVQ 6_ ATLLA 11_ RGLCR 16_ AWGGT 21_ CGAAL 26_ TGTSI 31_ SQVPR 36_ RLPRG 41_ LHCSA 46_ AAHSS 51_ EQSLV 56_ PSPPE 61_ PRQRP 66_ TKALV 71_ PFEDL 76_ FGQAP 81_ GGERD 86_ KASFL 91_ QTVQK 96_ FAEHS 101_ VRKRG 106_ HIDFI 111_ YLALR 116_ KMREY 121_ GVERD 126_ LAVYN 131_ QLLNI 136_ FPKEV 141_ FRPRN 146_ IIQRI 151_ FVHYP 156_ RQQEC 161_ GIAVL 166_ EQMEN 171_ HGVMP 176_ NKETE 181_ FLLIQ 186_ IFGRK 191_ SYPML 196_ KLVRL 201_ KLWFP 206_ RFMNV 211_ NPFPV 216_ PRDLP 221_ QDPVE 226_ LAMFG 231_ LRHME 236_ PDLSA 241_ RVTIY 246_ QVPLP 251_ KDSTG 256_ AADPP 261_ QPHIV 266_ GIQSP 271_ DQQAA 276_ LARHN 281_ PARPV 286_ FVEGP 291_ FSLWL 296_ RNKCV 301_ YYHIL 306_ RADLL 311_ PPEER 316_ EVEET 321_ PEEWN 326_ LYYPM 331_ QLDLE 336_ YVRSG 341_ WDNYE 346_ FDINE 351_ VEEGP 356_ VFAMC 361_ MAGAH 366_ DQATM 371_ AKWIQ 376_ GLQET 381_ NPTLA 386_ QIPVV 391_ FRLAG 396_ STREL 401_ QTSSA 406_ GLEEP 411_ PLPED 416_ HQEED 421_ DNLQR 426_QQQGQ
1: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs (PubMed:25355951, PubMed:31281713). Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression (PubMed:25355951). Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (PubMed:25228397). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity)
2: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I