Methylosome protein 50 (MEP-50) (Androgen receptor cofactor p44) (WD repeat-containing protein 77) (p44/Mep50)
1_MRKET 6_ PPPLV 11_ PPAAR 16_ EWNLP 21_ PNAPA 26_ CMERQ 31_ LEAAR 36_ YRSDG 41_ ALLLG 46_ ASSLS 51_ GRCWA 56_ GSLWL 61_ FKDPC 66_ AAPNE 71_ GFCSA 76_ GVQTE 81_ AGVAD 86_ LTWVG 91_ ERGIL 96_ VASDS 101_ GAVEL 106_ WELDE 111_ NETLI 116_ VSKFC 121_ KYEHD 126_ DIVST 131_ VSVLS 136_ SGTQA 141_ VSGSK 146_ DICIK 151_ VWDLA 156_ QQVVL 161_ SSYRA 166_ HAAQV 171_ TCVAA 176_ SPHKD 181_ SVFLS 186_ CSEDN 191_ RILLW 196_ DTRCP 201_ KPASQ 206_ IGCSA 211_ PGYLP 216_ TSLAW 221_ HPQQS 226_ EVFVF 231_ GDENG 236_ TVSLV 241_ DTKST 246_ SCVLS 251_ SAVHS 256_ QCVTG 261_ LVFSP 266_ HSVPF 271_ LASLS 276_ EDCSL 281_ AVLDS 286_ SLSEL 291_ FRSQA 296_ HRDFV 301_ RDATW 306_ SPLNH 311_ SLLTT 316_ VGWDH 321_ QVVHH 326_ VVPTE 331_ PLPAP 336_GPASV
1: Non-catalytic component of the methylosome complex, composed of PRMT5, WDR77 and CLNS1A, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones (PubMed:11756452). This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The methylosome complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (PubMed:23071334)