2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (EC 2.5.1.108) (Diphthamide biosynthesis protein 2) (Diphtheria toxin resistance protein 2) (S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2)
1_MESMF 6_ SSPAE 11_ AALQR 16_ ETGVP 21_ GLLTP 26_ LPDLD 31_ GVYEL 36_ ERVAG 41_ FVRDL 46_ GCERV 51_ ALQFP 56_ DQLLG 61_ DAVAV 66_ AARLE 71_ ETTGS 76_ KMFIL 81_ GDTAY 86_ GSCCV 91_ DVLGA 96_ EQAGA 101_ QALIH 106_ FGPAC 111_ LSPPA 116_ RPLPV 121_ AFVLR 126_ QRSVA 131_ LELCV 136_ KAFEA 141_ QNPDP 146_ KAPVV 151_ LLSEP 156_ ACAHA 161_ LEALA 166_ TLLRP 171_ RYLDL 176_ LVSSP 181_ AFPQP 186_ VGSLS 191_ PEPMP 196_ LERFG 201_ RRFPL 206_ APGRR 211_ LEEYG 216_ AFYVG 221_ GSKAS 226_ PDPDL 231_ DPDLS 236_ RLLLG 241_ WAPGQ 246_ PFSSC 251_ CPDTG 256_ KTQDE 261_ GARAG 266_ RLRAR 271_ RRYLV 276_ ERARD 281_ ARVVG 286_ LLAGT 291_ LGVAQ 296_ HREAL 301_ AHLRN 306_ LTQAA 311_ GKRSY 316_ VLALG 321_ RPTPA 326_ KLANF 331_ PEVDV 336_ FVLLA 341_ CPLGA 346_ LAPQL 351_ SGSFF 356_ QPILA 361_ PCELE 366_ AACNP 371_ AWPPP 376_ GLAPH 381_ LTHYA 386_ DLLPG 391_ SPFHV 396_ ALPPP 401_ ESELW 406_ ETPDV 411_ SLITG 416_ DLRPP 421_ PAWKS 426_ SNDHG 431_ SLALT 436_ PRPQL 441_ ELAES 446_ SPAAS 451_ FLSSR 456_ SWQGL 461_ EPRLG 466_ QTPVT 471_ EAVSG 476_ RRGIA 481_IAYED
1: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:32576952). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity)