Selenoprotein S (SelS) (VCP-interacting membrane protein)
1_MERQE 6_ ESLSA 11_ RPALE 16_ TEGLR 21_ FLHTT 26_ VGSLL 31_ ATYGW 36_ YIVFS 41_ CILLY 46_ VVFQK 51_ LSARL 56_ RALRQ 61_ RQLDR 66_ AAAAV 71_ EPDVV 76_ VKRQE 81_ ALAAA 86_ RLKMQ 91_ EELNA 96_ QVEKH 101_ KEKLK 106_ QLEEE 111_ KRRQK 116_ IEMWD 121_ SMQEG 126_ KSYKG 131_ NAKKP 136_ QEEDS 141_ PGPST 146_ SSVLK 151_ RKSDR 156_ KPLRG 161_ GGYNP 166_ LSGEG 171_ GGACS 176_ WRPGR 181_RGPSS
1: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination