NAD-capped RNA hydrolase NUDT12 (DeNADding enzyme NUDT12) (EC 3.6.1.-) (NADH pyrophosphatase NUDT12) (EC 3.6.1.22) (Nucleoside diphosphate-linked moiety X motif 12) (Nudix motif 12)
1_MSSVK 6_ RSLKQ 11_ EIVTQ 16_ FHCSA 21_ AEGDI 26_ AKLTG 31_ ILSHS 36_ PSLLN 41_ ETSEN 46_ GWTAL 51_ MYAAR 56_ NGHPE 61_ IVQFL 66_ LEKGC 71_ DRSIV 76_ NKSRQ 81_ TALDI 86_ AVFWG 91_ YKHIA 96_ NLLAT 101_ AKGGK 106_ KPWFL 111_ TNEVE 116_ ECENY 121_ FSKTL 126_ LDRKS 131_ EKRNN 136_ SDWLL 141_ AKESH 146_ PATVF 151_ ILFSD 156_ LNPLV 161_ TLGGN 166_ KESFQ 171_ QPEVR 176_ LCQLN 181_ YTDIK 186_ DYLAQ 191_ PEKIT 196_ LIFLG 201_ VELEI 206_ KDKLL 211_ NYAGE 216_ VPREE 221_ EDGLV 226_ AWFAL 231_ GIDPI 236_ AAEEF 241_ KQRHE 246_ NCYFL 251_ HPPMP 256_ ALLQL 261_ KEKEA 266_ GVVAQ 271_ ARSVL 276_ AWHSR 281_ YKFCP 286_ TCGNA 291_ TKIEE 296_ GGYKR 301_ LCLKE 306_ DCPSL 311_ NGVHN 316_ TSYPR 321_ VDPVV 326_ IMQVI 331_ HPDGT 336_ KCLLG 341_ RQKRF 346_ PPGMF 351_ TCLAG 356_ FIEPG 361_ ETIED 366_ AVRRE 371_ VEEES 376_ GVKVG 381_ HVQYV 386_ ACQPW 391_ PMPSS 396_ LMIGC 401_ LALAV 406_ STEIK 411_ VDKNE 416_ IEDAR 421_ WFTRE 426_ QVLDV 431_ LTKGK 436_ QQAFF 441_ VPPSR 446_ AIAHQ 451_ LIKHW 456_IRINP
1: mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA (PubMed:31101919, PubMed:31875550). The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (PubMed:31101919). Preferentially acts on NAD-capped transcripts in response to nutrient stress (PubMed:31101919). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP (PubMed:12790796). May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (PubMed:12790796). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)