SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)
1_MEDGT 6_ PKHII 11_ QMTGF 16_ KMEEK 21_ EALVK 26_ LLLKL 31_ DCTFI 36_ KSEKY 41_ KNCTH 46_ LIAER 51_ LCKSE 56_ KFLAA 61_ CAAGK 66_ WILTK 71_ DYIIH 76_ SAKSG 81_ RWLDE 86_ TTYEW 91_ GYKIE 96_ KDSRY 101_ SPQMQ 106_ SAPKR 111_ WREEL 116_ KRTGA 121_ PGAFH 126_ RWKVV 131_ LLVRT 136_ DKRSD 141_ SLIRV 146_ LEAGK 151_ ANVIL 156_ PKSSP 161_ SGITH 166_ VIASN 171_ ARIKA 176_ EKEKD 181_ NFKAP 186_ FYPIQ 191_ YLGDF 196_ LLEKE 201_ IQNDE 206_ DSQTN 211_ SVWTE 216_ HSNEE 221_ TNKDF 226_ RKDAG 231_ FLEMK 236_ GALRE 241_ TMYRT 246_ QKEMQ 251_ NHEDV 256_ NVGSI 261_ LIQHH 266_ KKEKF 271_ SGSSK 276_ DLKFV 281_ KMRNT 286_ FGSHT 291_ YENQK 296_ EIKKK 301_ DEDIQ 306_ RSYTL 311_ RRKRK 316_ KGKES 321_ NCKKG 326_ VEHEK 331_ IKSTL 336_ RRHIY 341_ NRDQK 346_ EMKNS 351_ IFAEY 356_ AKESK 361_ AMAIK 366_ TDVDV 371_ VEIKN 376_ TLRKH 381_ IYRAQ 386_ AVRYN 391_ CIRID 396_ KQPVY 401_ NVEVK 406_ NAEFP 411_ RGVLN 416_ LIESL 421_ IEGHF 426_ FKEAI 431_ EELST 436_ LQAHY 441_ IPPVC 446_ VLHAL 451_ LENVL 456_ QDNID 461_ TFSGR 466_ YFHIL 471_ SALLH 476_ LHPPW 481_ KSPAM 486_ SRYYL 491_ ELFQC 496_ PTCMK 501_ GAWSL 506_ VEVLI 511_ RSCLF 516_ NESFC 521_ HQISE 526_ NIGSK 531_ VLHLT 536_ LLKFF 541_ FNLIE 546_ SEVQH 551_ LSQKL 556_ YDWSD 561_ SQNLK 566_ ITGKA 571_ MLLEI 576_ FWSGS 581_ ETSGL 586_ LTKPV 591_ NMLLE 596_ WTIYS 601_ HKEKF 606_ KSNDV 611_ FKHEL 616_ AYLLA 621_ GILGA 626_ AIDYW 631_ IFLGL 636_ KMGRN 641_ VMRHM 646_ SDDLG 651_ SYVSL 656_ SCDDF 661_ SSQEL 666_ EIFIC 671_ SFSSS 676_ WLQMF 681_ VAEAV 686_ FKKLC 691_ LQSSG 696_ SVSSE 701_ PLSLQ 706_ KMVYS 711_ YLPAL 716_ GKTGV 721_ LGSGK 726_ IQVSK 731_ KIGQR 736_ PCFDS 741_ QRTLL 746_ MLNGT 751_ KQKQV 756_ EGLPE 761_ LLDLN 766_ LAKCS 771_ SSLKK 776_ LKKKS 781_ EGELS 786_ CSKEN 791_ CPSVV 796_ KKMNF 801_ HKTNL 806_ KGETA 811_ LHRAC 816_ INNQV 821_ EKLIL 826_ LLSLP 831_ GIDIN 836_ VKDNA 841_ GWTPL 846_ HEACN 851_ YGNTV 856_ CVQEI 861_ LQRCP 866_ EVDLL 871_ TQVDG 876_ VTPLH 881_ DALSN 886_ GHVEI 891_ GKLLL 896_ QHGGP 901_ VLLQQ 906_ RNAKG 911_ ELPLD 916_ YVVSP 921_ QIKEE 926_ LFAIT 931_ KIEDT 936_ VENFH 941_ AQAEK 946_ HFHYQ 951_ QLEFG 956_ SFLLS 961_ RMLLN 966_ FCSIF 971_ DLSSE 976_ FILAS 981_ KGLTH 986_ LNELL 991_ MACKS 996_ HKETT 1001_ SVHTD 1006_ WLLDL 1011_ YAGNI 1016_ KTLQK 1021_ LPHIL 1026_ KELPE 1031_ NLKVC 1036_ PGVHT 1041_ EALMI 1046_ TLEMM 1051_CRSVM
1: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674)