Golgi reassembly-stacking protein 1 (Golgi peripheral membrane protein p65) (Golgi phosphoprotein 5) (GOLPH5) (Golgi reassembly-stacking protein of 65 kDa) (GRASP65)
1_MGLGV 6_ SAEQP 11_ AGGAE 16_ GFHLH 21_ GVQEN 26_ SPAQQ 31_ AGLEP 36_ YFDFI 41_ ITIGH 46_ SRLNK 51_ ENDTL 56_ KALLK 61_ ANVEK 66_ PVKLE 71_ VFNMK 76_ TMRVR 81_ EVEVV 86_ PSNMW 91_ GGQGL 96_ LGASV 101_ RFCSF 106_ RRASE 111_ QVWHV 116_ LDVEP 121_ SSPAA 126_ LAGLR 131_ PYTDY 136_ VVGSD 141_ QILQE 146_ SEDFF 151_ TLIES 156_ HEGKP 161_ LKLMV 166_ YNSKS 171_ DSCRE 176_ VTVTP 181_ NAAWG 186_ GEGSL 191_ GCGIG 196_ YGYLH 201_ RIPTQ 206_ PPSYH 211_ KKPPG 216_ TPPPS 221_ ALPLG 226_ APPPD 231_ ALPPG 236_ PTPED 241_ SPSLE 246_ TGSRQ 251_ SDYME 256_ ALLQA 261_ PGSSM 266_ EDPLP 271_ GPGSP 276_ SHSAP 281_ DPDGL 286_ PHFME 291_ TPLQP 296_ PPPVQ 301_ RVMDP 306_ GFLDV 311_ SGISL 316_ LDNSN 321_ ASVWP 326_ SLPSS 331_ TELTT 336_ TAVST 341_ SGPED 346_ ICSSS 351_ SSHER 356_ GGEAT 361_ WSGSE 366_ FEVSF 371_ LDSPG 376_ AQAQA 381_ DHLPQ 386_ LTLPD 391_ SLTSA 396_ ASPED 401_ GLSAE 406_ LLEAQ 411_ AEEEP 416_ ASTEG 421_ LDTGT 426_ EAEGL 431_DSQAQ
1: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936)