Calsyntenin-3 (Alcadein-beta) (Alc-beta)
1_MTLLL 6_ LPLLL 11_ ASLLA 16_ SCSCN 21_ KANKH 26_ KPWIE 31_ AEYQG 36_ IVMEN 41_ DNTVL 46_ LNPPL 51_ FALDK 56_ DAPLR 61_ YAGEI 66_ CGFRL 71_ HGSGV 76_ PFEAV 81_ ILDKA 86_ TGEGL 91_ IRAKE 96_ PVDCE 101_ AQKEH 106_ TFTIQ 111_ AYDCG 116_ EGPDG 121_ ANTKK 126_ SHKAT 131_ VHVRV 136_ NDVNE 141_ FAPVF 146_ VERLY 151_ RAAVT 156_ EGKLY 161_ DRILR 166_ VEAID 171_ GDCSP 176_ QYSQI 181_ CYYEI 186_ LTPNT 191_ PFLID 196_ NDGNI 201_ ENTEK 206_ LQYSG 211_ ERLYK 216_ FTVTA 221_ YDCGK 226_ KRAAD 231_ DAEVE 236_ IQVKP 241_ TCKPS 246_ WQGWN 251_ KRIEY 256_ APGAG 261_ SLALF 266_ PGIRL 271_ ETCDE 276_ PLWNI 281_ QATIE 286_ LQTSH 291_ VAKGC 296_ DRDNY 301_ SERAL 306_ RKLCG 311_ AATGE 316_ VDLLP 321_ MPGPN 326_ ANWTA 331_ GLSVH 336_ YSQDS 341_ SLIYW 346_ FNGTQ 351_ AVQVP 356_ LGGPS 361_ GLGSG 366_ PQDSL 371_ SDHFT 376_ LSFWM 381_ KHGVT 386_ PNKGK 391_ KEEET 396_ IVCNT 401_ VQNED 406_ GFSHY 411_ SLTVH 416_ GCRIA 421_ FLYWP 426_ LLESA 431_ RPVKF 436_ LWKLE 441_ QVCDD 446_ EWHHY 451_ ALNLE 456_ FPTVT 461_ LYTDG 466_ ISFDP 471_ ALIHD 476_ NGLIH 481_ PPRRE 486_ PALMI 491_ GACWT 496_ EEKNK 501_ EKEKG 506_ DNSTD 511_ TTQGD 516_ PLSIH 521_ HYFHG 526_ YLAGF 531_ SVRSG 536_ RLESR 541_ EVIEC 546_ LYACR 551_ EGLDY 556_ RDFES 561_ LGKGM 566_ KVHVN 571_ PSQSL 576_ LTLEG 581_ DDVET 586_ FNHAL 591_ QHVAY 596_ MNTLR 601_ FATPG 606_ VRPLR 611_ LTTAV 616_ KCFSE 621_ ESCVS 626_ IPEVE 631_ GYVVV 636_ LQPDA 641_ PQILL 646_ SGTAH 651_ FARPA 656_ VDFEG 661_ TNGVP 666_ LFPDL 671_ QITCS 676_ ISHQV 681_ EAKKD 686_ ESWQG 691_ TVTDT 696_ RMSDE 701_ IVHNL 706_ DGCEI 711_ SLVGD 716_ DLDPE 721_ RESLL 726_ LDTTS 731_ LQQRG 736_ LELTN 741_ TSAYL 746_ TIAGV 751_ ESITV 756_ YEEIL 761_ RQARY 766_ RLRHG 771_ AALYT 776_ RKFRL 781_ SCSEM 786_ NGRYS 791_ SNEFI 796_ VEVNV 801_ LHSMN 806_ RVAHP 811_ SHVLS 816_ SQQFL 821_ HRGHQ 826_ PPPEM 831_ AGHSL 836_ ASSHR 841_ NSMIP 846_ SAATL 851_ IIVVC 856_ VGFLV 861_ LMVVL 866_ GLVRI 871_ HSLHR 876_ RVSGA 881_ GGPPG 886_ ASSDP 891_ KDPDL 896_ FWDDS 901_ ALTII 906_ VNPME 911_ SYQNR 916_ QSCVT 921_ GAVGG 926_ QQEDE 931_ DSSDS 936_ EVADS 941_ PSSDE 946_ RRIIE 951_TPPHR
1: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (PubMed:25352602). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane (PubMed:25352602). Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron (By similarity). May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2 (PubMed:34673103). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (Probable) (PubMed:12972431)
2: Adipose-specific isoform that plays a key role in adaptive thermogenesis. Facilitates the efficient use of stored triglyceride by promoting multilocular morphology of thermogenic adipocytes: acts by inhibiting the activity of CIDEA and CIDEC on lipid droplets, thereby preventing lipid droplet fusion and facilitating lipid utilization. May also participate in adaptive thermogenesis by promoting sympathetic innervation of thermogenic adipose tissue: acts by driving secretion of neurotrophic factor S100B from brown adipocytes, stimulating neurite outgrowth from sympathetic neurons