Neuralized-like protein 2
1_MAAAS 6_ EPVDS 11_ GALWG 16_ LERPE 21_ PPPTR 26_ FHRVH 31_ GANIR 36_ VDPSG 41_ TRATR 46_ VESFA 51_ HGVCF 56_ SREPL 61_ APGQV 66_ FLVEI 71_ EEKEL 76_ GWCGH 81_ LRLGL 86_ TALDP 91_ ASLAP 96_ VPEFS 101_ LPDLV 106_ NLGHT 111_ WVFAI 116_ TRHHN 121_ RVPRE 126_ GRPEA 131_ EAAAP 136_ SRPPT 141_ LLVEP 146_ YLRIE 151_ QFRIP 156_ RDRLV 161_ GRSRP 166_ GLYSH 171_ LLDQL 176_ YELNV 181_ LPPTA 186_ RRSRL 191_ GVLFC 196_ PRPDG 201_ TADMH 206_ IIING 211_ EDMGP 216_ SARGL 221_ PAAQP 226_ LYAVV 231_ DVFAS 236_ TKSVR 241_ LVQLE 246_ YGLPS 251_ LQTLC 256_ RLVIQ 261_ RSMVH 266_ RLAID 271_ GLHLP 276_KELKD
1: Plays an important role in the process of myofiber differentiation and maturation. Probable substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of proteins. Probably contributes to catalysis through recognition and positioning of the substrate and the ubiquitin-conjugating enzyme. During myogenesis, controls the ubiquitination and degradation of the specific pool of CTNNB1/beta-catenin located at the sarcolemma (By similarity)