Junctophilin-2 (JP-2) (Junctophilin type 2) [Cleaved into: Junctophilin-2 N-terminal fragment (JP2NT)]
1_MSGGR 6_ FDFDD 11_ GGAYC 16_ GGWEG 21_ GKAHG 26_ HGLCT 31_ GPKGQ 36_ GEYSG 41_ SWNFG 46_ FEVAG 51_ VYTWP 56_ SGNTF 61_ EGYWS 66_ QGKRH 71_ GLGIE 76_ TKGRW 81_ LYKGE 86_ WTHGF 91_ KGRYG 96_ IRQSS 101_ SSGAK 106_ YEGTW 111_ NNGLQ 116_ DGYGT 121_ ETYAD 126_ GGTYQ 131_ GQFTN 136_ GMRHG 141_ YGVRQ 146_ SVPYG 151_ MAVVV 156_ RSPLR 161_ TSLSS 166_ LRSEH 171_ SNGTV 176_ APDSP 181_ ASPAS 186_ DGPAL 191_ PSPAI 196_ PRGGF 201_ ALSLL 206_ ANAEA 211_ AARAP 216_ KGGGL 221_ FQRGA 226_ LLGKL 231_ RRAES 236_ RTSVG 241_ SQRSR 246_ VSFLK 251_ SDLSS 256_ GASDA 261_ ASTAS 266_ LGEAA 271_ EGADE 276_ AAPFE 281_ ADIDA 286_ TTTET 291_ YMGEW 296_ KNDKR 301_ SGFGV 306_ SERSS 311_ GLRYE 316_ GEWLD 321_ NLRHG 326_ YGCTT 331_ LPDGH 336_ REEGK 341_ YRHNV 346_ LVKDT 351_ KRRML 356_ QLKSN 361_ KVRQK 366_ VEHSV 371_ EGAQR 376_ AAAIA 381_ RQKAE 386_ IAASR 391_ TSHAK 396_ AKAEA 401_ AEQAA 406_ LAANQ 411_ ESNIA 416_ RTLAR 421_ ELAPD 426_ FYQPG 431_ PEYQK 436_ RRLLQ 441_ EILEN 446_ SESLL 451_ EPPDR 456_ GAGAA 461_ GLPQP 466_ PRESP 471_ QLHER 476_ ETPRP 481_ EGGSP 486_ SPAGT 491_ PPQPK 496_ RPRPG 501_ VSKDG 506_ LLSPG 511_ AWNGE 516_ PSGEG 521_ SRSVT 526_ PSEGA 531_ GRRSP 536_ ARPAT 541_ ERMAI 546_ EALQA 551_ PPAPS 556_ REPEV 561_ ALYQG 566_ YHSYA 571_ VRTTP 576_ PEPPP 581_ FEDQP 586_ EPEVS 591_ GSESA 596_ PSSPA 601_ TAPLQ 606_ APTLR 611_ GPEPA 616_ RETPA 621_ KLEPK 626_ PIIPK 631_ AEPRA 636_ KARKT 641_ EARGL 646_ TKAGA 651_ KKKAR 656_ KEAAL 661_ AAEAE 666_ VEVEE 671_ VPNTI 676_ LICMV 681_ ILLNI 686_ GLAIL 691_FVHLL
1: Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity)
2: Transcription repressor required to safeguard against the deleterious effects of cardiac stress. Generated following cleavage of the Junctophilin-2 chain by calpain in response to cardiac stress in cardiomyocytes. Following cleavage and release from the membrane, translocates to the nucleus, binds DNA and represses expression of genes implicated in cell growth and differentiation, hypertrophy, inflammation and fibrosis. Modifies the transcription profile and thereby attenuates pathological remodeling in response to cardiac stress. Probably acts by competing with MEF2 transcription factors and TATA-binding proteins