1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (hPLCD4) (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4)
1_MASLL 6_ QDQLT 11_ TDQDL 16_ LLMQE 21_ GMPMR 26_ KVRSK 31_ SWKKL 36_ RYFRL 41_ QNDGM 46_ TVWHA 51_ RQARG 56_ SAKPS 61_ FSISD 66_ VETIR 71_ NGHDS 76_ ELLRS 81_ LAEEL 86_ PLEQG 91_ FTIVF 96_ HGRRS 101_ NLDLM 106_ ANSVE 111_ EAQIW 116_ MRGLQ 121_ LLVDL 126_ VTSMD 131_ HQERL 136_ DQWLS 141_ DWFQR 146_ GDKNQ 151_ DGKMS 156_ FQEVQ 161_ RLLHL 166_ MNVEM 171_ DQEYA 176_ FSLFQ 181_ AADTS 186_ QSGTL 191_ EGEEF 196_ VQFYK 201_ ALTKR 206_ AEVQE 211_ LFESF 216_ SADGQ 221_ KLTLL 226_ EFLDF 231_ LQEEQ 236_ KERDC 241_ TSELA 246_ LELID 251_ RYEPS 256_ DSGKL 261_ RHVLS 266_ MDGFL 271_ SYLCS 276_ KDGDI 281_ FNPAC 286_ LPIYQ 291_ DMTQP 296_ LNHYF 301_ ICSSH 306_ NTYLV 311_ GDQLC 316_ GQSSV 321_ EGYIR 326_ ALKRG 331_ CRCVE 336_ VDVWD 341_ GPSGE 346_ PVVYH 351_ GHTLT 356_ SRILF 361_ KDVVA 366_ TVAQY 371_ AFQTS 376_ DYPVI 381_ LSLET 386_ HCSWE 391_ QQQTM 396_ ARHLT 401_ EILGE 406_ QLLST 411_ TLDGV 416_ LPTQL 421_ PSPEE 426_ LRRKI 431_ LVKGK 436_ KLTLE 441_ EDLEY 446_ EEEEA 451_ EPELE 456_ ESELA 461_ LESQF 466_ ETEPE 471_ PQEQN 476_ LQNKD 481_ KKKKS 486_ KPILC 491_ PALSS 496_ LVIYL 501_ KSVSF 506_ RSFTH 511_ SKEHY 516_ HFYEI 521_ SSFSE 526_ TKAKR 531_ LIKEA 536_ GNEFV 541_ QHNTW 546_ QLSRV 551_ YPSGL 556_ RTDSS 561_ NYNPQ 566_ ELWNA 571_ GCQMV 576_ AMNMQ 581_ TAGLE 586_ MDICD 591_ GHFRQ 596_ NGGCG 601_ YVLKP 606_ DFLRD 611_ IQSSF 616_ HPEKP 621_ ISPFK 626_ AQTLL 631_ IQVIS 636_ GQQLP 641_ KVDKT 646_ KEGSI 651_ VDPLV 656_ KVQIF 661_ GVRLD 666_ TARQE 671_ TNYVE 676_ NNGFN 681_ PYWGQ 686_ TLCFR 691_ VLVPE 696_ LAMLR 701_ FVVMD 706_ YDWKS 711_ RNDFI 716_ GQYTL 721_ PWTCM 726_ QQGYR 731_ HIHLL 736_ SKDGI 741_ SLRPA 746_ SIFVY 751_ ICIQE 756_GLEGD
1: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation
2: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3