Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)
1_MAMSF 6_ EWPWQ 11_ YRFPP 16_ FFTLQ 21_ PNVDT 26_ RQKQL 31_ AAWCS 36_ LVLSF 41_ CRLHK 46_ QSSMT 51_ VMEAQ 56_ ESPLF 61_ NNVKL 66_ QRKLP 71_ VESIQ 76_ IVLEE 81_ LRKKG 86_ NLEWL 91_ DKSKS 96_ SFLIM 101_ WRRPE 106_ EWGKL 111_ IYQWV 116_ SRSGQ 121_ NNSVF 126_ TLYEL 131_ TNGED 136_ TEDEE 141_ FHGLD 146_ EATLL 151_ RALQA 156_ LQQEH 161_ KAEII 166_ TVSDG 171_RGVKF
1: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. The ESCRT-II complex may be involved in facilitating the budding of certain RNA viruses