Zinc transporter 2 (ZnT-2) (Solute carrier family 30 member 2)
1_MEAKE 6_ KQHLL 11_ DARPA 16_ IRSYT 21_ GSLWQ 26_ EGAGW 31_ IPLPR 36_ PGLDL 41_ QAIEL 46_ AAQSN 51_ HHCHA 56_ QKGPD 61_ SHCDP 66_ KKGKA 71_ QRQLY 76_ VASAI 81_ CLLFM 86_ IGEVV 91_ EILGA 96_ LVSVL 101_ SIWVV 106_ TGVLV 111_ YLAVE 116_ RLISG 121_ DYEID 126_ GGTML 131_ ITSGC 136_ AVAVN 141_ IIMGL 146_ TLHQS 151_ GHGHS 156_ HGTTN 161_ QQEEN 166_ PSVRA 171_ AFIHV 176_ IGDFM 181_ QSMGV 186_ LVAAY 191_ ILYFK 196_ PEYKY 201_ VDPIC 206_ TFVFS 211_ ILVLG 216_ TTLTI 221_ LRDVI 226_ LVLME 231_ GTPKG 236_ VDFTA 241_ VRDLL 246_ LSVEG 251_ VEALH 256_ SLHIW 261_ ALTVA 266_ QPVLS 271_ VHIAI 276_ AQNTD 281_ AQAVL 286_ KTASS 291_ RLQGK 296_ FHFHT 301_ VTIQI 306_ EDYSE 311_ DMKDC 316_QACQG
1: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:17065149, PubMed:21289295, PubMed:22733820, PubMed:25657003, PubMed:25808614, PubMed:30893306). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (PubMed:19496757). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (PubMed:25808614)
2: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane